INT171557

Context Info Confidence 0.23 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.27 Pain Relevance 0.14

plasma membrane (SLAMF1)

SLAMF1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 26 58.24 chemokine 10 57.04 cytokine 10 54.16 ketamine 10 5.00 Inflammatory response 8 5.00 anesthesia 6 5.00 fibrosis 2 5.00 metalloproteinase 2 5.00 Calcitonin gene-related peptide 2 5.00

Disease Link Frequency Relevance Heat Pneumonia 12 58.24 Hypersensitivity 34 57.32 Adhesions 6 46.24 Asthma 50 5.00 INFLAMMATION 22 5.00 Disease 14 5.00 Overdose 6 5.00 Breast Cancer 6 5.00 Lymphatic System Cancer 4 5.00 Aging 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The downregulation of SLAM gene expression observed here after allergen challenge, which induces a Th2 response, is consistent with this earlier observation.

Negative_regulation (downregulation) of Gene_expression (expression) of SLAM gene

1) Confidence 0.23 Published 2002 Journal Genome Biol Section Body Doc Link PMC115222 Disease Relevance 0.17 Pain Relevance 0.08

In addition, levels of soluble SLAM in serum were found to be lower in patients with elevated IgE than in normal controls, and low production of SLAM was associated with a Th2 response in vivo [36].

Negative_regulation (lower) of Gene_expression (levels) of SLAM

2) Confidence 0.14 Published 2002 Journal Genome Biol Section Body Doc Link PMC115222 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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