INT171589

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (APOC3) transport (APOC3) extracellular space (APOC3)
small molecule metabolic process (APOC3) extracellular region (APOC3) lipid metabolic process (APOC3)
Anatomy Link Frequency
plasma 2
APOC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 8 82.80 Quite High
agonist 13 47.88 Quite Low
Inflammation 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 1 97.20 Very High Very High Very High
Disorder Of Lipid Metabolism 19 96.88 Very High Very High Very High
Increased Venous Pressure Under Development 3 95.20 Very High Very High Very High
Targeted Disruption 6 82.40 Quite High
Hyperlipidemia 39 81.60 Quite High
Gallbladder Disease 1 78.72 Quite High
Van Bogaert's Disease 3 61.04 Quite High
Stress 8 5.00 Very Low Very Low Very Low
Coronary Artery Disease 8 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although it is not clear how this protein contributes to the familial hypertriglyceridemic syndromes, recent studies have found that two classes of drugs that are effective in lowering plasma TG in these patients act through suppression of APOC3 gene transcription in rodents [37,38].
Transcription (transcription) of APOC3 in plasma associated with syndrome
1) Confidence 0.71 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.42 Pain Relevance 0
increases APOA5 [54–56] and decreases APOC3 [57] transcription, resulting in a plasma TAG lowering effect, thereby, together with increased HDL concentrations, reducing the risk for atherosclerosis in humans [58].
Transcription (transcription) of APOC3 in plasma associated with increased venous pressure under development and disorder of lipid metabolism
2) Confidence 0.38 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.84 Pain Relevance 0.15

General Comments

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