INT171683

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.28
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TXK) nucleus (TXK) DNA binding (TXK)
cytoplasm (TXK)
Anatomy Link Frequency
myocardium 2
TXK (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 41 100.00 Very High Very High Very High
antagonist 6 67.24 Quite High
Pain 2 64.64 Quite High
adenocard 18 10.84 Low Low
ischemia 13 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 98.40 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 9 97.48 Very High Very High Very High
Breast Cancer 129 94.96 High High
Metastasis 12 91.20 High High
Pain 2 64.64 Quite High
Toxicity 6 42.92 Quite Low
Disease Progression 3 41.00 Quite Low
Disease 18 39.64 Quite Low
Exanthema 10 34.64 Quite Low
Diarrhoea 10 33.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in the development of small molecule tyrosine kinase inhibitors (smTKIs) for targeting EGFR in various cancer types
Negative_regulation (development) of Negative_regulation (inhibitors) of tyrosine kinase associated with cancer
1) Confidence 0.06 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.19 Pain Relevance 0
But again, the mechanism of preconditioning the human myocardium may not be applicable to all species as suggested by the need to combine the inhibition of PKC and tyrosine kinase to abort the protection of preconditioning in pigs. [30]
Negative_regulation (combine) of Negative_regulation (inhibition) of tyrosine kinase in myocardium associated with kinase c
2) Confidence 0.06 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.12 Pain Relevance 0.46
These findings indicate that tyrosine kinase inhibitor (TKI) blockade of EGFR has potential in the treatment and chemoprevention of DCIS [47] (Table 1).
Negative_regulation (inhibitor) of Negative_regulation (blockade) of tyrosine kinase associated with noninfiltrating intraductal carcinoma
3) Confidence 0.06 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.97 Pain Relevance 0

General Comments

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