INT171686

Context Info Confidence 0.31 First Reported 2002 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 9 Disease Relevance 11.88 Pain Relevance 1.07

Anatomy Link Frequency connective tissue 1 extracellular matrix 1 kidney 1 asp1 (Mus musculus)

Pain Link Frequency Relevance Heat alcohol 6 94.96 cva 174 87.88 imagery 44 5.00 headache 6 5.00 ischemia 4 5.00 Buprenorphine 3 5.00 methadone 3 5.00 Migraine 2 5.00

Disease Link Frequency Relevance Heat Cerebral Aneurysm 328 100.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 93 99.76 Autosomal Disorder 12 99.24 Rupture 54 98.56 Autosomal Dominant Polycystic Kidney 2 98.04 Aneurism 60 97.04 Disease 51 96.56 Syndrome 8 95.64 Marfan Syndrome 2 94.64 Increased Venous Pressure Under Development 28 94.24

Sentences Mentioned In

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Anatomy

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The IAS is also strengthening its commitment to regional development, expanding our involvement in three main areas: collaboration with regional societies, engagement with regional conferences, and supporting and expanding IAS membership in each region.

IAS Binding (expanding) of

1) Confidence 0.31 Published 2006 Journal Retrovirology Section Body Doc Link PMC1762023 Disease Relevance 0.49 Pain Relevance 0

In addition to the large international conferences, the IAS also organizes the biennial Pathogenesis, Treatment and Prevention conference, which will be held next in Sydney, Australia, 22–25 July 2007.

IAS Binding (organizes) of

2) Confidence 0.31 Published 2006 Journal Retrovirology Section Body Doc Link PMC1762023 Disease Relevance 0.56 Pain Relevance 0

The IAS is also strengthening its commitment to regional development, expanding our involvement in three main areas: collaboration with regional societies, engagement with regional conferences, and supporting and expanding IAS membership in each region.

IAS Binding (strengthening) of

3) Confidence 0.31 Published 2006 Journal Retrovirology Section Body Doc Link PMC1762023 Disease Relevance 0.49 Pain Relevance 0

Thus, the most effective ways to decrease morbidity and mortality associated with IAs are to prevent formation of IA in the population and to identify asymptomatic unruptured IA in affected individuals prior to rupture.

IAs Binding (associated) of associated with cerebral aneurysm and rupture

4) Confidence 0.08 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1097731 Disease Relevance 2.09 Pain Relevance 0.22

Unruptured IAs are associated with a variable risk of aneurysmal rupture that increases with size of the aneurysms [8,9].

IAs Binding (associated) of associated with cerebral aneurysm, rupture and aneurism

5) Confidence 0.06 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1097731 Disease Relevance 2.00 Pain Relevance 0.20

Initial indications of a genetic component were based on collections of case reports that suggested that IAs are associated with some rare simple Mendelian disorders, e.g. autosomal dominant polycystic kidney disease, Ehlers Danlos syndrome type IV and the Marfan syndrome [13].

IAs Binding (associated) of in kidney associated with autosomal disorder, syndrome, autosomal dominant polycystic kidney, marfan syndrome and disease

6) Confidence 0.06 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC119849 Disease Relevance 1.61 Pain Relevance 0.05

The familial occurrence of IAs not associated with known simple Mendelian disorders was first noted in 1942 [18] and, since then, nearly one hundred case reports and review articles have been published.

IAs Binding (associated) of associated with autosomal disorder

7) Confidence 0.04 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC119849 Disease Relevance 1.80 Pain Relevance 0.08

Disruption of the extracellular matrix is likely to be a factor in the pathophysiology of IA, because IAs are associated with heritable connective tissue and extracellular matrix disorders (7).

IAs Binding (associated) of in extracellular matrix associated with cerebral aneurysm

8) Confidence 0.02 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2722006 Disease Relevance 1.42 Pain Relevance 0.26

Disruption of the extracellular matrix is likely to be a factor in the pathophysiology of IA, because IAs are associated with heritable connective tissue and extracellular matrix disorders (7).

IAs Binding (associated) of in connective tissue associated with cerebral aneurysm

9) Confidence 0.01 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2722006 Disease Relevance 1.42 Pain Relevance 0.26

General Comments

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