INT171719

Context Info Confidence 0.01 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 0.28

extracellular space (IL4, TNF, CXCL10) extracellular region (IL4, TNF, CXCL10) signal transduction (TNF, CXCL10) plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)

Anatomy Link Frequency T lymphocytes 2 IL4 (Homo sapiens) TNF (Homo sapiens) CXCL10 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 10 96.12 chemokine 10 95.88 antagonist 2 86.48 cytokine 7 77.08 Inflammatory marker 2 50.00 Inflammatory response 1 27.84 rheumatoid arthritis 3 5.00 corticosteroid 1 5.00 anesthesia 1 5.00 lidocaine 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 12 96.12 Contact Dermatitis 28 94.12 Dermatitis 4 84.36 Hypersensitivity 11 67.12 Adhesions 4 5.00 Disease 3 5.00 Rheumatoid Arthritis 3 5.00 Pressure And Volume Under Development 2 5.00 Papular Skin Disease 1 5.00 Apoptosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

But here IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.

IL-4 Positive_regulation (potentiating) of TNF-alpha Positive_regulation (induction) of IP-10 in T lymphocytes associated with inflammation

1) Confidence 0.01 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.67 Pain Relevance 0.28

General Comments

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