INT171745

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.32
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCR3) extracellular space (CCR3) cell adhesion (CCR3)
plasma membrane (CCR3) signal transducer activity (CCR3)
Anatomy Link Frequency
sputum 2
Th2 cells 1
CCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 40 98.14 Very High Very High Very High
cytokine 35 96.72 Very High Very High Very High
chemokine 12 92.96 High High
Inflammatory response 1 89.64 High High
antagonist 10 83.84 Quite High
Inflammatory marker 2 50.00 Quite Low
rheumatoid arthritis 3 26.20 Quite Low
agonist 14 5.00 Very Low Very Low Very Low
corticosteroid 13 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 100 98.72 Very High Very High Very High
INFLAMMATION 40 98.14 Very High Very High Very High
Dermatitis 4 78.36 Quite High
Hypersensitivity 67 78.12 Quite High
Contact Dermatitis 28 76.16 Quite High
Adhesions 8 54.96 Quite High
Eosinophilia 2 40.60 Quite Low
Rheumatoid Arthritis 3 26.20 Quite Low
Increased Venous Pressure Under Development 1 20.88 Low Low
Disease 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The allergen-induced levels of beta-chain mRNA and CCR3 mRNA in sputum-derived cells were inhibited by TPIASM8, but no significant effects on cell surface protein expression of CCR3 and the beta-chain were found.
Transcription (mRNA) of CCR3 in sputum
1) Confidence 0.37 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.73 Pain Relevance 0.04
The allergen-induced levels of beta-chain mRNA and CCR3 mRNA in sputum-derived cells were inhibited by TPIASM8, but no significant effects on cell surface protein expression of CCR3 and the beta-chain were found.
Transcription (levels) of CCR3 in sputum
2) Confidence 0.37 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.74 Pain Relevance 0.04
T lymphocytes with polarized cytokine production (Th1 and Th2) show a different distribution of inflammatory CR, with CXCR3 and CCR5 transcripts markedly enhanced in Th1 cells and increased amounts of transcripts for CCR3, CCR4 and CCR8 in Th2 cells [39].
Transcription (transcripts) of CCR3 in Th2 cells associated with inflammation and cytokine
3) Confidence 0.30 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.85 Pain Relevance 0.37

General Comments

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