INT171754

Context Info Confidence 0.26 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.72 Pain Relevance 0.42

cell adhesion (CCR8) plasma membrane (CCR8) signal transducer activity (CCR8)

CCR8 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 20 99.58 Inflammation 20 82.04 antagonist 4 59.60 cytokine 14 50.20 Inflammatory marker 4 50.00 rheumatoid arthritis 6 5.00 corticosteroid 2 5.00 anesthesia 2 5.00 Inflammatory response 2 5.00 lidocaine 2 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 22 94.84 INFLAMMATION 24 82.40 Contact Dermatitis 56 67.24 Dermatitis 8 57.48 Adhesions 8 5.00 Disease 6 5.00 Rheumatoid Arthritis 6 5.00 Pressure And Volume Under Development 4 5.00 Papular Skin Disease 2 5.00 Apoptosis 2 5.00

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Key:

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

They have a broad array of functional T1- and T2-associated chemokine receptors, but also express high levels of CCR2 and CCR8 which allow resting as well as activated Th IL-10 cells to display a significant migratory capacity to CCL2 and CCL1 [46].

Positive_regulation (activated) of Gene_expression (express) of CCR8 associated with chemokine

1) Confidence 0.26 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.36 Pain Relevance 0.21

They have a broad array of functional T1- and T2-associated chemokine receptors, but also express high levels of CCR2 and CCR8 which allow resting as well as activated Th IL-10 cells to display a significant migratory capacity to CCL2 and CCL1 [46].

Positive_regulation (levels) of Gene_expression (express) of CCR8 associated with chemokine

2) Confidence 0.26 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.36 Pain Relevance 0.21

General Comments

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