INT171767

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.48
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP15) protein modification process (MMP15)
Anatomy Link Frequency
connective tissue 6
MMP15 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Inflammatory mediators 3 100.00 Very High Very High Very High
chemokine 9 99.84 Very High Very High Very High
Inflammation 21 86.48 High High
metalloproteinase 55 50.00 Quite Low
psoriasis 12 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
spinal inflammation 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 84 100.00 Very High Very High Very High
INFLAMMATION 24 100.00 Very High Very High Very High
Cancer 47 99.96 Very High Very High Very High
Glioma 2 99.84 Very High Very High Very High
Necrosis 3 99.72 Very High Very High Very High
Skin Cancer 5 94.48 High High
Lung Cancer 1 92.68 High High
Pancreatic Cancer 1 89.28 High High
Breast Cancer 6 88.16 High High
Metastasis 9 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A hypothetical role for MMP2 and MMP15 in the Blau syndrome is that aberrant expression of MMP2 and MMP15 could inappropriately degrade connective tissue, which, in turn, could release stored cytokines and inflammatory mediators, such as tumor necrosis factor ?
Positive_regulation (as) of Gene_expression (expression) of MMP15 in connective tissue associated with necrosis, inflammatory mediators, cancer, syndrome and cytokine
1) Confidence 0.38 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0.75 Pain Relevance 0.19
A hypothetical role for MMP2 and MMP15 in the Blau syndrome is that aberrant expression of MMP2 and MMP15 could inappropriately degrade connective tissue, which, in turn, could release stored cytokines and inflammatory mediators, such as tumor necrosis factor ?
Positive_regulation (aberrant) of Gene_expression (expression) of MMP15 in connective tissue associated with necrosis, inflammatory mediators, cancer, syndrome and cytokine
2) Confidence 0.38 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0.62 Pain Relevance 0.17
A hypothetical role for MMP2 and MMP15 in the Blau syndrome is that aberrant expression of MMP2 and MMP15 could inappropriately degrade connective tissue, which, in turn, could release stored cytokines and inflammatory mediators, such as tumor necrosis factor ?
Positive_regulation (for) of Gene_expression (expression) of MMP15 in connective tissue associated with necrosis, inflammatory mediators, cancer, syndrome and cytokine
3) Confidence 0.38 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0.62 Pain Relevance 0.17
Chemokine CXCL12 upregulates MMP-15 expression in glioma cells and serves as an effector of CXCR4 signaling in these cells by promoting cell invasion [46].
Positive_regulation (upregulates) of Gene_expression (expression) of MMP-15 associated with chemokine and glioma
4) Confidence 0.15 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 2.49 Pain Relevance 0.05

General Comments

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