INT171906

Context Info Confidence 0.08 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.55 Pain Relevance 0.52

nucleoplasm (MAPK1, MAPK14) response to stress (MAPK1, MAPK14) cytoplasm (MAPK1, MAPK14) cytosol (MAPK1, MAPK14) signal transduction (MAPK1, MAPK14) nucleus (MAPK1, MAPK14)

MAPK1 (Homo sapiens) MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 64 98.78 cytokine 24 95.76 Inflammation 20 88.00 metalloproteinase 6 65.16 Arthritis 14 5.00 Osteoarthritis 6 5.00 Pain 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 64 98.78 Osteoarthritis 12 96.40 Stress 130 94.72 INFLAMMATION 18 88.00 Synovitis 10 69.92 Death 12 68.12 Apoptosis 18 67.68 Shock 18 20.08 Heat Stress Disorders 16 5.00 Arthritis 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the synovial membrane of RA patients, all three known MAPK/SAPK signalling pathways are activated, including the extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK) and p38 pathways [58,59].

extracellular signal-regulated protein kinase Positive_regulation (activated) of Gene_expression (pathways) of p38 associated with rheumatoid arthritis

1) Confidence 0.08 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 0.77 Pain Relevance 0.26

In the synovial membrane of RA patients, all three known MAPK/SAPK signalling pathways are activated, including the extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK) and p38 pathways [58,59].

ERK Positive_regulation (activated) of Gene_expression (pathways) of p38 associated with rheumatoid arthritis

2) Confidence 0.08 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 0.77 Pain Relevance 0.26

General Comments

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