INT171922

Context Info Confidence 0.44 First Reported 2001 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.31 Pain Relevance 0.34

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)

Anatomy Link Frequency fibroblasts 2 upper 2 GOPC (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 106 99.54 rheumatoid arthritis 32 87.20 Arthritis 7 63.60 Inflammation 12 42.16 metalloproteinase 9 27.60 addiction 6 18.12 cytokine 14 5.00 antagonist 7 5.00 imagery 7 5.00 ischemia 5 5.00

Disease Link Frequency Relevance Heat Shock 9 98.86 Stress 66 97.94 Rheumatoid Arthritis 32 87.20 Contracture 8 72.48 Arthritis 6 63.60 Equinus Deformity 1 63.08 Heat Stress Disorders 8 55.44 Hyperplasia 1 55.44 Pressure And Volume Under Development 12 49.00 Disease 20 45.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Fig. 7Foot splints can also be held to the fixator using Velcro straps

Positive_regulation (held) of Fig Binding (splints) of

1) Confidence 0.44 Published 2006 Journal Strategies Trauma Limb Reconstr Section Body Doc Link PMC2780592 Disease Relevance 0.20 Pain Relevance 0

As for the soluble species, total free VEGF in all compartments decreased with increasing VEGF-binding affinity of either VEGFR1 or VEGFR2 – presumably through enhanced internalization of complexed VEGF (Fig. 6B).

Positive_regulation (increasing) of Fig Binding (internalization) of

2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0

As for the soluble species, total free VEGF in all compartments decreased with increasing VEGF-binding affinity of either VEGFR1 or VEGFR2 – presumably through enhanced internalization of complexed VEGF (Fig. 6B).

Positive_regulation (enhanced) of Fig Binding (internalization) of

3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0

Furthermore, agonist stimulation caused an increased association between the hIP and Rab5aS34N (Fig. 5; upper panel).

Positive_regulation (increased) of Fig Binding (association) of in upper associated with agonist

4) Confidence 0.11 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.26

Interestingly, recent data from our laboratory have shown that shear stress induces a complete response of the heat shock factor (HSF)-1/HSP70 pathway in synovial fibroblasts by inducing DNA binding of HSF-1 (Fig. 1) and the subsequent overexpression of HSP70 [11].

Positive_regulation (inducing) of Fig Binding (binding) of in fibroblasts associated with stress and shock

5) Confidence 0.09 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.11 Pain Relevance 0.08

General Comments

This test has worked.