INT171990

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Context Info
Confidence 0.05
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.58
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DMD, VDR) nucleoplasm (VDR) cytosol (DMD)
signal transduction (VDR) cell morphogenesis (VDR) cytoskeleton (DMD)
Anatomy Link Frequency
hip 1
DMD (Homo sapiens)
VDR (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 208 96.88 Very High Very High Very High
cytokine 4 46.44 Quite Low
Arthritis 8 7.88 Low Low
Pain 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 212 96.88 Very High Very High Very High
Osteoporosis 186 91.36 High High
Frailty 67 89.52 High High
Osteoporotic Fractures 18 89.04 High High
Osteophyte 24 84.24 Quite High
Disease 50 76.48 Quite High
Hip Fractures 10 72.00 Quite High
Spinal Osteophytosis 4 71.20 Quite High
Syndrome 8 36.40 Quite Low
Intervertebral Disk Degeneration 4 17.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A meta-analytical approach incorporating the results from 16 studies revealed a weak contribution of the allelic variant at the 3' end of the gene to the variation of BMD values [84], while a more recent meta-analysis concluded that BMD is associated with VDR polymorphism at high confidence levels and that both genetic and nongenetic factors can interfere with the unmasking of the effects of VDR variants on bone phenotype [85].
BMD Binding (associated) of VDR
1) Confidence 0.05 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.09 Pain Relevance 0
The association of polymorphism of the gene for vitamin D receptor (VDR) with BMD [40] was followed by investigations of this gene's possible association with OA.
BMD Binding (association) of vitamin D receptor associated with osteoarthritis
2) Confidence 0.04 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.68 Pain Relevance 0.20
The association of polymorphism of the gene for vitamin D receptor (VDR) with BMD [40] was followed by investigations of this gene's possible association with OA.
BMD Binding (association) of VDR associated with osteoarthritis
3) Confidence 0.04 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.68 Pain Relevance 0.20
Since that original report, conflicting data have been published on the association of the diallelic BsmI restriction-fragment-length polymorphism (RFLP) with the VDR gene and BMD in both premenopausal [59,60,61,62] and postmenopausal [63,64,65,66,67,68] women.
BMD Binding (association) of VDR
4) Confidence 0.04 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.22 Pain Relevance 0
Protein, calcium, and vitamin D supplementation is associated with increased hip BMD and a reduction in falls.
BMD Binding (associated) of vitamin D in hip
5) Confidence 0.00 Published 2010 Journal Osteoporos Int Section Abstract Doc Link PMC2974929 Disease Relevance 0.93 Pain Relevance 0

General Comments

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