INT171997

Context Info Confidence 0.25 First Reported 2001 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 4.97 Pain Relevance 1.67

mitochondrion (ERAL1) RNA binding (ERAL1) rRNA binding (ERAL1) intracellular (ERAL1) ribosome biogenesis (ERAL1)

Anatomy Link Frequency plasma 1 T cells 1 ERAL1 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 133 100.00 Arthritis 30 100.00 Osteoarthritis 84 99.80 imagery 15 98.84 Pain 83 87.84 Inflammation 36 77.60 Rsd 1 61.36 Angina 2 56.96 reflex sympathetic dystrophy 1 55.44 allodynia 1 30.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 178 100.00 Arthritis 21 100.00 Frailty 34 99.80 Disorder Of Lipid Metabolism 44 99.52 Heart Disease 2 97.44 Rheumatic Diseases 2 96.36 Disease 86 95.72 Arthropathy 3 93.04 Pain 73 87.84 Syndrome 3 86.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Another important finding of the present study is that ERA patients exhibit low plasma HDL-cholesterol levels at baseline.

Gene_expression (exhibit) of ERA in plasma associated with rheumatoid arthritis and disorder of lipid metabolism

1) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.00 Pain Relevance 0.28

Other polymorphic genes, such as the one encoding ERa, have been shown to modulate the effect of the VDR gene in the determination of BMD, confirming the existence of gene?

Gene_expression (one) of ERa

2) Confidence 0.10 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.06 Pain Relevance 0

The HERA trial required patients to have a normal left ventricular ejection fraction (LVEF) ?

Gene_expression (trial) of HERA

3) Confidence 0.09 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1959236 Disease Relevance 0.72 Pain Relevance 0.06

Further analysis directly comparing the ERA and OA patient groups, again using a threshold of 10% greater than the highest OA patient MFI value, provided evidence for a distinguishing activation profile in the CD4+ T cells and CD20+ B cells in patients with ERA (Table 2).

Gene_expression (comparing) of ERA in T cells associated with rheumatoid arthritis and osteoarthritis

4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.29 Pain Relevance 0.34

Diagnostic imaging is not useful for plantar fascitiis but may show erosive enthesitis in ERA.

Gene_expression (enthesitis) of ERA associated with imagery and arthritis

5) Confidence 0.04 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2323000 Disease Relevance 1.92 Pain Relevance 0.99

General Comments

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