INT172096

Context Info Confidence 0.01 First Reported 2000 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.32 Pain Relevance 0.48

plasma membrane (HLA-E)

Anatomy Link Frequency T-cell 3 HLA-E (Homo sapiens) Il27ra (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 10 95.40 rheumatoid arthritis 68 86.40 tolerance 6 84.64 Arthritis 15 79.60 Osteoarthritis 1 8.96 Kinase C 12 5.00 cytokine 9 5.00 abatacept 4 5.00 cva 4 5.00 chemokine 2 5.00

Disease Link Frequency Relevance Heat General Immunology 4 98.24 Disease 35 96.08 INFLAMMATION 9 95.40 Targeted Disruption 9 94.48 Rheumatoid Arthritis 68 86.40 Arthritis 17 80.64 Autoimmune Disease 31 72.08 Experimental Arthritis 1 56.48 Congenital Anomalies 3 46.64 Osteoarthritis 1 8.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The new model is based on a transgene encoded T-cell receptor (TCR) that recognizes a self-component in the context of the mouse MHC class II molecule I-Ag7 (formerly known as I-ANOD).

MHC Binding (recognizes) of T-cell receptor in T-cell

1) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129986 Disease Relevance 0.98 Pain Relevance 0.39

Signal 1 is delivered by the T-cell receptor (TCR) recognizing the antigenic peptide within the context of the major histocompatibility complex (MHC) molecule.

MHC Binding (recognizing) of T-cell receptor in T-cell

2) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.17 Pain Relevance 0.04

Signal 1 is delivered by the T-cell receptor (TCR) recognizing the antigenic peptide within the context of the major histocompatibility complex (MHC) molecule.

MHC Binding (recognizing) of T-cell receptor in T-cell

3) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.17 Pain Relevance 0.04

General Comments

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