INT1721

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Context Info
Confidence 0.42
First Reported 1979
Last Reported 2010
Negated 7
Speculated 2
Reported most in Abstract
Documents 148
Total Number 159
Disease Relevance 86.82
Pain Relevance 16.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HP)
Anatomy Link Frequency
plasma 4
blood 3
heart 3
kidney 2
stage 1 2
HP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 82 100.00 Very High Very High Very High
opioid receptor 47 100.00 Very High Very High Very High
fluoxetine 1 99.98 Very High Very High Very High
antagonist 361 99.92 Very High Very High Very High
narcan 17 99.84 Very High Very High Very High
bradykinin 55 99.68 Very High Very High Very High
Desipramine 1 99.66 Very High Very High Very High
imagery 71 99.52 Very High Very High Very High
anesthesia 13 99.46 Very High Very High Very High
Pain 40 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 4440 100.00 Very High Very High Very High
Manic Depressive Disorder 372 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 241 100.00 Very High Very High Very High
Ulcers 23 100.00 Very High Very High Very High
Pancreatic Cancer 17 100.00 Very High Very High Very High
Dyspnea 18 99.82 Very High Very High Very High
Albuminuria 192 99.80 Very High Very High Very High
Increased Venous Pressure Under Development 329 99.68 Very High Very High Very High
Chronic Renal Failure 186 99.66 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 44 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fucosylated haptoglobin was observed more frequently at the advanced stage of PC and disappeared after operation.
Negative_regulation (disappeared) of haptoglobin associated with pancreatic cancer
1) Confidence 0.42 Published 2008 Journal Proteomics Section Abstract Doc Link 18646007 Disease Relevance 1.75 Pain Relevance 0.11
Imipramine, chloripramine, desipramine, and fluoxetine inhibited binding to filters whereas 5-hydroxytryptamine and ethanol were ineffective.
Negative_regulation (inhibited) of binding associated with desipramine and fluoxetine
2) Confidence 0.36 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6330301 Disease Relevance 0 Pain Relevance 0.15
The percent inhibition of binding by naloxone is approximately 90% in the caudate nucleus and medial thalamus for the period 30-60 min after injection; therefore, this method is associated with a high level of specific binding to opiate receptors compared with nonspecific binding sites.
Negative_regulation (inhibition) of binding in medial associated with narcan, opiate and thalamus
3) Confidence 0.34 Published 1985 Journal J Comput Assist Tomogr Section Abstract Doc Link 2982931 Disease Relevance 0 Pain Relevance 1.22
Our results support the concept 1) the interaction between Hp infection and NSAID on gastro-duodenal ulcerations is antagonistic, 2) the Hp and NSAID are independent risk factors for peptic ulcerations in humans, 3) there is no need for the Hp eradication in NSAID-treated patients, and 4) the rate of ulcer complications (hemorrhage and perforation) remains constant despite the decrease in Hp and ulcer prevalence.
Negative_regulation (decrease) of Hp associated with ulcers, cinod, cva and infection
4) Confidence 0.34 Published 2002 Journal Med. Sci. Monit. Section Abstract Doc Link 12218957 Disease Relevance 2.14 Pain Relevance 1.04
The hematological data revealed normocytic, slightly hypochromic anemia, a persistently elevated reticulocyte count, slightly increased bilirubin, and decreased haptoglobin.
Negative_regulation (decreased) of haptoglobin in reticulocyte associated with hypochromic anemia
5) Confidence 0.33 Published 1990 Journal Jpn. J. Med. Section Abstract Doc Link 2214354 Disease Relevance 1.05 Pain Relevance 0.09
It is possible, by washing, to reduce nonspecific binding to low levels.
Negative_regulation (reduce) of binding
6) Confidence 0.31 Published 1979 Journal Brain Res. Section Abstract Doc Link 228806 Disease Relevance 0 Pain Relevance 0.38
Therefore, a measure of haptoglobin level was added for the last three patients to assess for the presence of hemolysis.
Negative_regulation (measure) of haptoglobin associated with hemolysis
7) Confidence 0.22 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.16 Pain Relevance 0.25
Mild hemolysis was suspected because of decreased level of the serum haptoglobin.
Negative_regulation (decreased) of serum haptoglobin associated with hemolysis
8) Confidence 0.21 Published 1993 Journal Rinsho Shinkeigaku Section Abstract Doc Link 8370205 Disease Relevance 1.50 Pain Relevance 0.27
The same associations were observed for proteins in univariate analysis with a decrease in ApoA1, haptoglobin and an increase of A2M in NASH.
Negative_regulation (decrease) of haptoglobin associated with nash(non-alcoholic steatohepatitis)
9) Confidence 0.21 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.92 Pain Relevance 0.03
The only significant changes seen after premedication, during anesthesia and during surgery were a decrease in serum concentrations of alpha 1-antitrypsin and haptoglobin.
Negative_regulation (decrease) of haptoglobin associated with anesthesia
10) Confidence 0.17 Published 1992 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 1374604 Disease Relevance 0.82 Pain Relevance 0.10
The protein binding of indomethacin is decreased in the presence of cinmetacin.
Negative_regulation (decreased) of binding
11) Confidence 0.13 Published 1986 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2880970 Disease Relevance 0.09 Pain Relevance 0.09
The percent inhibition of binding by naloxone is approximately 90% in the caudate nucleus and medial thalamus for the period 30-60 min after injection; therefore, this method is associated with a high level of specific binding to opiate receptors compared with nonspecific binding sites.
Negative_regulation (inhibition) of binding in caudate nucleus associated with narcan, opiate and thalamus
12) Confidence 0.12 Published 1985 Journal J Comput Assist Tomogr Section Abstract Doc Link 2982931 Disease Relevance 0 Pain Relevance 1.22
It may be included in lifestyle changes aiming to prevent or reduce high BP.


Negative_regulation (reduce) of BP associated with hypertension
13) Confidence 0.09 Published 2010 Journal Nutr J Section Body Doc Link PMC2989300 Disease Relevance 1.06 Pain Relevance 0.03
In contrast to the EUROPA study, BP reduction was a key indicator of reduced cardiovascular event rates in the PROGRESS study, given the greater reductions in BP and cardiovascular events seen with 4 mg perindopril in combination with indapamide, than with 4 mg perindopril alone.
Negative_regulation (reductions) of BP
14) Confidence 0.09 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 0.40 Pain Relevance 0
Reduction in cardiovascular events by the amlodipine–perindopril regimen was associated not only with a greater reduction of BP, but also with a faster pulse, and beneficial alterations in body weight, serum high density lipoprotein (HDL) cholesterol, triglycerides, creatinine, and potassium, and fasting glucose levels (Poulter et al 2005).
Negative_regulation (reduction) of BP in body associated with body weight and disorder of lipid metabolism
15) Confidence 0.09 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 0.57 Pain Relevance 0.03
The EUROPA investigators proposed the reduction in cardiovascular events by perindopril in the EUROPA study was greater than might be expected for the observed reduction in BP (mean 5/2 mm Hg), and may have been due to antiatherosclerotic effects of ACE inhibition.
Negative_regulation (reduction) of BP
16) Confidence 0.09 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 0.57 Pain Relevance 0
While healthy volunteers showed no relevant decrease in BP, in hypertensive patients a reduction in BP in doses of 100 mg to 400 mg occurred (p < 0.05); effects were more pronounced after md compared to sd.
Neg (no) Negative_regulation (decrease) of BP associated with hypertension
17) Confidence 0.07 Published 2007 Journal Biomarker Insights Section Abstract Doc Link PMC2717814 Disease Relevance 0.22 Pain Relevance 0.17
While healthy volunteers showed no relevant decrease in BP, in hypertensive patients a reduction in BP in doses of 100 mg to 400 mg occurred (p < 0.05); effects were more pronounced after md compared to sd.
Negative_regulation (reduction) of BP associated with hypertension
18) Confidence 0.07 Published 2007 Journal Biomarker Insights Section Abstract Doc Link PMC2717814 Disease Relevance 0.16 Pain Relevance 0.16
In many papers, BP reduction through lactotripeptides has been suggested to be due to inhibition of the renin-angiotensin system, which plays an important role in regulating arterial pressure.
Negative_regulation (reduction) of BP associated with hypertension
19) Confidence 0.07 Published 2010 Journal Nutr J Section Body Doc Link PMC2989300 Disease Relevance 0.73 Pain Relevance 0.07
It may be included in lifestyle changes aiming to prevent or reduce high BP.


Negative_regulation (reduce) of BP
20) Confidence 0.07 Published 2010 Journal Nutr J Section Abstract Doc Link PMC2989300 Disease Relevance 0.43 Pain Relevance 0

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