INT172460

Context Info Confidence 0.46 First Reported 2002 Last Reported 2007 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.55 Pain Relevance 0.04

Golgi apparatus (Rab27b) plasma membrane (Rab27b) GTPase activity (Rab27b) cytoplasm (Rab27b)

Rab27b (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 6 86.32 imagery 4 35.28 anesthesia 3 5.00 Inflammatory mediators 2 5.00 cytokine 1 5.00 ketamine 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 141 99.18 Syndrome 11 80.88 Piebaldism 3 80.64 Anaphylaxis 10 64.52 Disease 6 60.80 Choroideremia 15 51.40 Hypersensitivity 6 5.00 Retina Disease 4 5.00 Sprains And Strains 3 5.00 Immunodeficiency 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Conversely, in Rab27b KO or double KO BMMCs, the histamine-positive granules appeared more clustered (Figure 4) in a subset of BMMCs, more specifically 32% of Rab27b KO (n = 34) and 63% of double KO (n = 8) BMMCs, compared with no obvious accumulation of granules in wild-type (n = 55), Rab27a+/ash (n = 11), Rab27aash/ash (n = 36), Rab27b+/?

Neg (no) Positive_regulation (accumulation) of Rab27b associated with targeted disruption

1) Confidence 0.46 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.73 Pain Relevance 0.04

If the Rab27a mutant proteins Rab27aT23N and Rab27aN133I acted as strong dominant-negative mutants, as they do in cell culture [34,38], the transgenic lines generated should exhibit a phenotype resembling ashen mice, possibly with additional phenotypes due to inactivation of Rab27b as well.

Positive_regulation (inactivation) of Rab27b associated with targeted disruption

2) Confidence 0.35 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.82 Pain Relevance 0

General Comments

This test has worked.