INT172465

Context Info Confidence 0.41 First Reported 2002 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.71 Pain Relevance 0.27

Golgi apparatus (Rab27a, Rab27b) GTPase activity (Rab27a, Rab27b) endosome (Rab27a) intracellular (Rab27a) cytoplasm (Rab27b) pigmentation (Rab27a)

Anatomy Link Frequency mast cell 2 Rab27a (Mus musculus) Rab27b (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 12 99.76 cytokine 2 78.52 imagery 8 5.00 Inflammatory mediators 4 5.00 anesthesia 4 5.00 ketamine 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Choroideremia 15 97.52 Targeted Disruption 190 94.32 Hypersensitivity 12 84.08 Disease 8 76.56 Anaphylaxis 20 70.40 Syndrome 13 69.60 Sprains And Strains 6 52.88 Piebaldism 4 37.60 Hemorrhagic Diathesis 2 17.04 Retina Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that Rab27b and to a lesser extent Rab27a are associated with serotonin-containing mast cell secretory granules.

Rab27a Binding (associated) of Rab27b in mast cell associated with serotonin

1) Confidence 0.41 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.54 Pain Relevance 0.14

These results suggest that Rab27b and to a lesser extent Rab27a are associated with serotonin-containing mast cell secretory granules.

Rab27a Binding (associated) of Rab27b in mast cell associated with serotonin

2) Confidence 0.41 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.54 Pain Relevance 0.14

Our recent finding that Rab27b shows functional redundancy with Rab27a further suggests that Rab27a-related Rabs may be involved in CHM [28].

Rab27a Binding (redundancy) of Rab27b associated with choroideremia

3) Confidence 0.30 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.63 Pain Relevance 0

General Comments

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