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Context Info
Confidence 0.04
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.62
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (THRB) nucleus (THRB) enzyme binding (THRB)
DNA binding (THRB)
Anatomy Link Frequency
MCF7 1
liver 1
thyroid 1
hind limb 1
THRB (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 4 86.88 High High
Inflammation 46 60.32 Quite High
diabetic neuropathy 2 57.04 Quite High
Central nervous system 2 49.12 Quite Low
cytokine 20 25.00 Low Low
dexamethasone 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 84 99.92 Very High Very High Very High
Inflammatory Breast Neoplasms 228 99.04 Very High Very High Very High
Abscess 2 97.12 Very High Very High Very High
Breast Cancer 55 96.80 Very High Very High Very High
Obesity 3 93.64 High High
Increased Venous Pressure Under Development 2 93.28 High High
Cancer 121 81.44 Quite High
Neuropathic Pain 1 66.80 Quite High
Endometriosis (extended) 2 57.20 Quite High
Diabetic Neuropathy 2 57.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Variants of the thyroid hormone receptor (TR)
Gene_expression (receptor) of thyroid hormone in thyroid
1) Confidence 0.04 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
We studied hepatic gene expression of the newly identified thyroid hormone receptor (TR) cofactor DOR/TP53INP2 together with TRs in a rat model of aseptic abscesses induced by injecting intramuscular turpentine-oil into each hind limb.
Gene_expression (expression) of thyroid hormone receptor in hind limb associated with abscess
2) Confidence 0.03 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2977073 Disease Relevance 0.10 Pain Relevance 0
Expression of c-myb was found to correlate inversely with c-erb2 expression, and was higher in non-IBC samples (63% versus 38%).
Gene_expression (expression) of c-erb2 associated with inflammatory breast neoplasms
3) Confidence 0.02 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.54 Pain Relevance 0.03
Expression of the ER and PgR genes, c-myb, c-erb2, c-myc, c-fos, the epidermal growth factor receptor (EGFR) gene, and pS2 (a small secreted protein isolated from MCF7 cells after induction by 17?
Gene_expression (Expression) of c-erb2 in MCF7
4) Confidence 0.02 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.85 Pain Relevance 0
Thyroid hormone produces changes in hormone levels and gene profiles that resemble fasting states, in which insulin signaling should be reduced, and thyroid hormone stimulates liver gluconeogenesis, which increases blood glucose levels [36].
Gene_expression (produces) of Thyroid hormone in liver
5) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901187 Disease Relevance 1.13 Pain Relevance 0.15

General Comments

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