INT172626

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.97
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (E2F1) nucleoplasm (E2F1) mitochondrion (E2F1)
nucleus (E2F1) DNA binding (E2F1) transcription factor binding (E2F1)
Anatomy Link Frequency
H69 1
nucleus 1
E2F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 98.42 Very High Very High Very High
Pain 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Cholecystokinin 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 13 99.30 Very High Very High Very High
Papillomavirus Infection 55 99.10 Very High Very High Very High
Small Cell Lung Cancer 63 98.00 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 71 89.76 High High
Cancer 111 75.44 Quite High
Cervical Cancer 2 68.96 Quite High
Lung Cancer 10 54.32 Quite High
Lichen Sclerosus Et Atrophicus 32 39.40 Quite Low
Reprotox - General 2 1 29.20 Quite Low
Metastasis 2 29.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cervical carcinogenesis triggered by high-risk type HPV infection, E7 inhibits Rb, resulting in the release of active host E2F-1, which positively regulates host p14ARF.
Localization (release) of E2F-1 associated with papillomavirus infection and infection
1) Confidence 0.78 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.25 Pain Relevance 0
The treatment of H69 human SCLC cells with capsaicin leads to a switch in E2F subtypes on cyclin E, TS, cdc25A and cdc6 promoters; E2F1–3 are dissociated from the promoter, and E2F4 and p130 are recruited.
Localization (recruited) of E2F1 in H69 associated with qutenza and small cell lung cancer
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.72 Pain Relevance 0.40
Acetylation of transcription factors can alter their ability to bind DNA (in the cases of E2F1, p53, EKLF, GATA1, and HNF-4), to interact with other proteins (c-Jun, TCF, ACTR, and HNF-4), or to remain in the nucleus (HNF-4).
Localization (cases) of E2F1 in nucleus
3) Confidence 0.14 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0

General Comments

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