INT172856

Context Info Confidence 0.08 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.16 Pain Relevance 0

peptidase activity (Lta4h) nucleus (Lta4h) cytoplasm (Lta4h)

Anatomy Link Frequency endothelial cells 1 Lta4h (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 1 45.88 cINOD 18 44.12 COX-2 inhibitor 10 5.00 aspirin 8 5.00 cytokine 3 5.00 Inflammation 3 5.00 antagonist 3 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Adhesions 3 97.16 Anaphylaxis 1 63.92 Cancer 76 46.96 Prostate Cancer 6 26.56 Colon Cancer 5 22.52 Targeted Disruption 4 20.16 Pancreatic Cancer 84 17.44 Skin Cancer 2 10.72 Apoptosis 39 5.00 Adenocarcinoma 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hydrolytic attack of LTA4 by leukotriene A4 hydrolase yields LTB4, a potent neutrophil chemoattractant and stimulator of leukocyte adhesion to endothelial cells.

Gene_expression (yields) of LTA4 in endothelial cells associated with adhesions

1) Confidence 0.08 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.