INT172964

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 10.62
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
endothelial cell 3
extracellular matrix 3
hepatocyte 1
Th17 cells 1
HGF 1
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 98.52 Very High Very High Very High
Arthritis 82 93.44 High High
antagonist 15 82.68 Quite High
Pain 15 66.40 Quite High
Neuropeptide 2 61.16 Quite High
chemokine 4 59.60 Quite High
cytokine 14 58.52 Quite High
metalloproteinase 32 57.72 Quite High
bradykinin 23 56.32 Quite High
Inflammatory marker 2 46.32 Quite Low
Disease Link Frequency Relevance Heat
Thymoma 4 99.08 Very High Very High Very High
Retinal Neovascularization 1 99.08 Very High Very High Very High
INFLAMMATION 39 98.52 Very High Very High Very High
Acute Liver Failure 22 97.84 Very High Very High Very High
Hypoxia 84 97.56 Very High Very High Very High
Cancer 710 96.96 Very High Very High Very High
Breast Cancer 55 96.00 Very High Very High Very High
Pressure And Volume Under Development 3 95.76 Very High Very High Very High
Wound Healing 51 95.04 Very High Very High Very High
Rheumatoid Arthritis 81 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mechanisms include: blocking the binding of VEGF121 and VEGF165 to the KDR/Flk-1 receptor, which mediates endothelial cell motility and proliferation; blocking phosphorylation of the tyrosine receptor; and blocking activation of the intracellular signaling kinases ERK, p38 MAPK, and p125 FAK [34,35].
VEGF Binding (binding) of in endothelial cell
1) Confidence 0.47 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.13 Pain Relevance 0.04
Angiotensin II is a known stimulus for the expression of vascular endothelial growth factor (VEGF), which is associated with the induction of retinal neovascularization (Aiello et al 1995; Gilbert et al 1998; Otani et al 2000; Okada et al 2001).
vascular endothelial growth factor Binding (associated) of associated with retinal neovascularization
2) Confidence 0.47 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.97 Pain Relevance 0.03
In conclusion, we observed that VEGF-VEGFRs interaction was a prerequisite against chemically-induced murine AHF, and that R2 was a major regulator of maintenance of the SEC architecture by attenuating the cytotoxicity and apoptosis of EC more than R1.
VEGF Binding (interaction) of associated with acute liver failure and apoptosis
3) Confidence 0.47 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.48 Pain Relevance 0
In contrast, the VEGF 164 protein product is partially soluble but also binds to extracellular matrix while VEGF 188 is not soluble and binds only to matrix proteoglycans.
VEGF 164 Binding (binds) of in extracellular matrix
4) Confidence 0.41 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0.35 Pain Relevance 0
In contrast, the VEGF 164 protein product is partially soluble but also binds to extracellular matrix while VEGF 188 is not soluble and binds only to matrix proteoglycans.
VEGF 188 Binding (binds) of in extracellular matrix
5) Confidence 0.41 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0.34 Pain Relevance 0
These mechanisms include: blocking the binding of VEGF121 and VEGF165 to the KDR/Flk-1 receptor, which mediates endothelial cell motility and proliferation; blocking phosphorylation of the tyrosine receptor; and blocking activation of the intracellular signaling kinases ERK, p38 MAPK, and p125 FAK [34,35].
VEGF Binding (binding) of in endothelial cell
6) Confidence 0.36 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.13 Pain Relevance 0.04
Th17 cells in synovial fluid are associated with increased VEGF-A production
VEGF Binding (associated) of in Th17 cells
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.52 Pain Relevance 0.15
COX: cyclooxygenase; CYP: cytochrome P450; IOD: integrated optical density; GC-MS: gas chromatography-mass spectrometry; LOX: lipoxygenase; MUFA: monounsaturated fatty acid; MVD: Micro vessel density; PUFA: polyunsaturated fatty acid; ROS: reactive oxygen species; RT-PCR: reverse transcriptase polymerase chain reaction; VEGFA: vascular endothelial growth factor A; AKT1: v-akt murine thymoma viral oncogene homolog 1.


vascular endothelial growth factor Binding (cytochrome P450) of associated with thymoma
8) Confidence 0.35 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.58 Pain Relevance 0
The protein product of VEGF 120 is soluble with low binding affinity for extracellular matrix.
VEGF 120 Binding (affinity) of in extracellular matrix
9) Confidence 0.31 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0.36 Pain Relevance 0
VEGFA is considered to be a potent and crucial angiogenic stimulator and promotes all steps in the cascade process of angiogenesis by binding to the extracellular domain of its receptor to activate the downstream proteins after the dimerization and autophosphorylation of the intracellular receptor tyrosine kinases [17].
VEGFA Binding (binding) of
10) Confidence 0.29 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.52 Pain Relevance 0.11
Of these, only vascular endothelial growth factor (VEGF) and CXCR4, showed additive responses to TGF-?
vascular endothelial growth factor Binding (only) of
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.59 Pain Relevance 0
50 mix DMEM:Hams F12 plus glutamine supplemented with VEGF-A164 (25 ng/ml) and cells allowed to migrate over 8 hr at 37°C.
VEGF-A164 Binding (supplemented) of
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.15 Pain Relevance 0
This transcription factor induces the expression of pro-angiogenic growth factors, such as vascular endothelial growth factor (VEGF), which in turn bind to and activate their respective receptors on the surface of endothelial cells, leading to angiogenesis [10,11].
vascular endothelial growth factor Binding (bind) of in endothelial cells
13) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 1.67 Pain Relevance 0.15
EGF-R, epithelial growth factor receptor; HMG-CoA, 3-Hydroxy-3-methylglutaryl-coenzyme A; VEGF-R, vascular endothelial growth factor receptor; MVD, microvascular density; PDGF-R, platelet derived growth factor receptor; HGF, hepatocyte growth factor receptor

Authors contributions

vascular endothelial growth factor Binding (receptor) of in hepatocyte
14) Confidence 0.06 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.41 Pain Relevance 0
EGF-R, epithelial growth factor receptor; HMG-CoA, 3-Hydroxy-3-methylglutaryl-coenzyme A; VEGF-R, vascular endothelial growth factor receptor; MVD, microvascular density; PDGF-R, platelet derived growth factor receptor; HGF, hepatocyte growth factor receptor

Authors contributions

vascular endothelial growth factor Binding (receptor) of in HGF
15) Confidence 0.02 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.41 Pain Relevance 0

General Comments

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