INT173091

Context Info Confidence 0.55 First Reported 2003 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.39 Pain Relevance 0.27

extracellular region (KDR) cytoplasmic membrane-bounded vesicle (KDR) plasma membrane (KDR) nucleus (KDR) cytoplasm (KDR)

Anatomy Link Frequency TFK-1 1 AsPC-1 1 KDR (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 3 92.00 cytokine 10 84.08 cva 50 80.40 Hippocampus 10 76.48 Neurotransmitter 8 5.00 ischemia 6 5.00 Bile 6 5.00 palliative 4 5.00 dexamethasone 3 5.00 Inflammation 3 5.00

Disease Link Frequency Relevance Heat Pancreatic Cancer 82 98.68 Cholangiocarcinoma 74 96.04 Pancreatitis 3 92.00 Cv General 4 Under Development 41 80.40 Cancer 103 62.80 Malignant Neoplastic Disease 9 56.72 Hypersensitivity 1 54.52 Hypoxia 50 50.00 Apoptosis 16 40.72 Recurrence 3 31.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

VEGF and VEGFR were also demonstrated in human pancreatic cancer cell lines, although, in contrast to the Itakura et al study, no VEGFR mRNA was detected in cultured Capan-1 cells (VEGFR-1 mRNA-positive cells were AsPC-1, Dan-G, and PANC-1; VEGFR-2 mRNA-positive cells were AsPC-1 and Dan-G) [83].

Neg (no) Transcription (detected) of VEGFR in AsPC-1 associated with pancreatic cancer

1) Confidence 0.55 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.72 Pain Relevance 0.09

In addition to growth factors, the RT-PCR study has demonstrated that both primary human MSCs and B10 cells express mRNA for VEGFR, CXCR4 and c-kit, cellular receptors known for close involvement in cellular migration (Figure 10).

Transcription (express) of VEGFR

2) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.20 Pain Relevance 0.18

VEGFR2 was found in EGI-1, HuH28 and OZ but not in TFK-1.

Neg (not) Transcription (found) of VEGFR2 in TFK-1

3) Confidence 0.18 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 0.47 Pain Relevance 0

General Comments

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