INT173103

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.11
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 96.00 Very High Very High Very High
agonist 1 90.04 High High
Dopamine 1 89.72 High High
Inflammation 22 76.84 Quite High
Central nervous system 1 64.16 Quite High
imagery 6 30.84 Quite Low
COX2 7 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxoplasmosis 1 99.82 Very High Very High Very High
Hypoxia 79 94.56 High High
American Trypanosomiasis 1 94.24 High High
Apoptosis 13 84.48 Quite High
Death 2 80.96 Quite High
Infection 89 78.52 Quite High
Cancer 117 77.00 Quite High
INFLAMMATION 22 76.84 Quite High
Disease 6 71.28 Quite High
Carcinoma 3 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional studies revealed that Toxoplasma infection rapidly increased the abundance of the HIF1?
Positive_regulation (increased) of Transcription (abundance) of HIF associated with toxoplasmosis
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.82 Pain Relevance 0.04
An increase in the protein level of HIF-1?
Positive_regulation (increase) of Transcription (level) of HIF
2) Confidence 0.49 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.70 Pain Relevance 0.14
to form the HIF-1 complex, and activation of transcription through HIF-1's binding to specific HREs in target sequences (see Figure 2).
Positive_regulation (activation) of Transcription (transcription) of HIF-1
3) Confidence 0.26 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.59 Pain Relevance 0.03

General Comments

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