INT173173

Context Info Confidence 0.38 First Reported 2003 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 2.59 Pain Relevance 1.64

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14) nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)

MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 81 98.56 cytokine 181 97.68 Osteoarthritis 142 95.84 Central nervous system 21 82.96 Inflammatory response 2 80.20 Nicotine 96 58.80 agonist 23 50.00 dexamethasone 19 38.56 antagonist 27 35.12 B1 receptor 7 32.00

Disease Link Frequency Relevance Heat Cancer 29 98.80 INFLAMMATION 85 98.56 Necrosis 6 98.56 Osteoarthritis 144 95.84 Apoptosis 54 94.56 Stress 37 91.52 Disease Progression 5 87.68 Hyperplasia 1 85.92 Pulmonary Disease 5 85.52 Disease 32 85.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, treatment with PE affects particularly the activation of MKK3 which in turn has an impact on the activation of p38-MAPK downstream (summarized in Figure 6).

Regulation (impact) of Positive_regulation (activation) of p38

1) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.69 Pain Relevance 0.25

On-going investigations continue to validate p38?

Spec (investigations) Regulation (continue) of Positive_regulation (validate) of p38

2) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.50 Pain Relevance 0.34

The activation of both p38 and ERK has been shown to lead to the release of TNF?

Regulation (lead) of Positive_regulation (activation) of p38

3) Confidence 0.10 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.24 Pain Relevance 0.15

Interestingly, the cAMP pathway can interact with the MAPK cascade. cAMP negatively regulates MAPK p38 activation, and thereby contributing to tumor necrosis factor (TNF)-?

Regulation (regulates) of Positive_regulation (activation) of p38 associated with necrosis and cancer

4) Confidence 0.09 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.77 Pain Relevance 0.21

These findings also agree with studies on other cell types demonstrating the critical role of ERK1/2 and p38 activation in the regulation of MMP-13 as well as with data showing that rhein reduces the IL-1?

Regulation (role) of Positive_regulation (activation) of p38

5) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.38 Pain Relevance 0.20

Role of p38 MAPK activation in the enhancing effect of epinephrine on proatherogenic cytokine production from IL-1?

Regulation (Role) of Positive_regulation (activation) of p38 associated with cytokine

6) Confidence 0.05 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.26

alone had small effects on p38 activation at this time point while control levels were virtually nonexistent.

Regulation (effects) of Positive_regulation (activation) of p38

7) Confidence 0.03 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.22

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