INT173178

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.66
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
hepatocyte 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 71.96 Quite High
agonist 46 50.00 Quite Low
Inflammation 12 19.12 Low Low
cytokine 15 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-eclampsia 5 93.32 High High
Stress 8 91.20 High High
Reprotox - General 1 1 86.16 High High
Apoptosis 57 70.96 Quite High
INFLAMMATION 21 63.68 Quite High
Death 6 54.96 Quite High
Hepatocellular Cancer 16 50.64 Quite High
Disease 4 41.00 Quite Low
Diabetes Mellitus 27 35.32 Quite Low
Tuberous Sclerosis 1 31.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
also been noted, suggesting a deregulation of PPAR?
Positive_regulation (suggesting) of Regulation (deregulation) of PPAR
1) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0.52 Pain Relevance 0.04
Several PPAR target genes, such as CYP4A1, CPT1, or CD36, were induced in the two hepatocyte cultures treated by 40??
Positive_regulation (induced) of Regulation (target) of PPAR in hepatocyte
2) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.14 Pain Relevance 0
It has been shown that its phosphorylation state contributes to the modulation of PPAR?
Positive_regulation (contributes) of Regulation (modulation) of PPAR
3) Confidence 0.34 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0 Pain Relevance 0

General Comments

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