INT173179

Context Info Confidence 0.29 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 13 Total Number 13 Disease Relevance 4.51 Pain Relevance 2.92

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14) nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)

Anatomy Link Frequency liver 2 MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 311 100.00 Central nervous system 169 99.34 Inflammation 136 98.60 Kinase C 1 93.44 ischemia 1 89.68 Eae 8 87.12 Osteoarthritis 37 82.88 Inflammatory response 22 73.72 fluoxetine 1 69.76 antidepressant 1 68.52

Disease Link Frequency Relevance Heat Stress 45 99.36 Disease 94 99.12 INFLAMMATION 164 98.60 Dementia 8 98.60 Renal Cancer 2 97.28 Dna Damage 1 95.60 Hepatocellular Cancer 9 94.96 Liver Cancer 6 93.60 Cancer 55 89.80 Cv Unclassified Under Development 2 89.68

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since this protein is one of most important members involved in the RAF/MEK/ERK signaling pathway, MAPK14 is associated with sorafenib, which is a drug used for the treatment of advanced renal cell carcinoma (primary kidney cancer) and advanced hepatocellular carcinoma (primary liver cancer).

MAPK14 Binding (associated) of in liver associated with liver cancer, hepatocellular cancer and renal cancer

1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.80 Pain Relevance 0.14

This effect occurs within minutes following a challenge with ET-1, and disappears after 45 and 60 min for the p-38 and SAP/JNK kinases, respectively.

p-38 Binding (min) of

2) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.08 Pain Relevance 0.04

MAPK and its linkage in cell culture to cytokine increases in response to stressors, p38?

p38 Binding (linkage) of associated with cytokine

3) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.31 Pain Relevance 0.41

MAPK as a therapeutic approach in some CNS disorders and provide causative links between p38?

p38 Binding (links) of associated with central nervous system

4) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.44 Pain Relevance 0.28

An in vivo causative link between p38?

p38 Binding (link) of

5) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.49 Pain Relevance 0.14

In addition to glial p38?

p38 Binding (addition) of

6) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.25 Pain Relevance 0.41

An interesting potential link between p38?

p38 Binding (link) of

7) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.38 Pain Relevance 0.36

There are also a variety of p38?

p38 Binding (variety) of

8) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.11 Pain Relevance 0.23

MAPK activation for up-regulated cytokine production by stressed glia and provided a link between p38?

p38 Binding (link) of associated with cytokine

9) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.25 Pain Relevance 0.40

For example, p38?

p38 Binding (example) of

10) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.12 Pain Relevance 0.19

In particular, p38 MAP kinase has been associated with oxidative stress [106] and has been reported to be constitutively active in mouse liver [107].

p38 MAP kinase Binding (associated) of in liver associated with stress

11) Confidence 0.10 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.54 Pain Relevance 0.03

Minutoli et al., demonstrated the abrogation of JNK and p38 signals, but enhancement of ERK 1/2 activity by disruption of the transcriptional factor NF-?

p38 Binding (abrogation) of

12) Confidence 0.06 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.25 Pain Relevance 0.04

Whether the interaction between GR and p38 MAPK accounts for nongenomic anti-inflammatory effects of glucocorticoids remains to be investigated.

p38 Binding (interaction) of associated with inflammation

13) Confidence 0.05 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.50 Pain Relevance 0.23

General Comments

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