INT173208

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 11.01
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CNBP) endoplasmic reticulum (CNBP) nucleus (CNBP)
DNA binding (CNBP) cytoplasm (CNBP)
Anatomy Link Frequency
plaque 1
beta cell 1
CNBP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 48 99.80 Very High Very High Very High
ischemia 15 98.08 Very High Very High Very High
Tetrahydrobiopterin 42 95.28 Very High Very High Very High
Inflammation 98 87.84 High High
Angina 2 85.04 High High
cytokine 11 76.24 Quite High
metalloproteinase 18 64.96 Quite High
Glutamate 4 47.88 Quite Low
agonist 2 43.48 Quite Low
chemokine 3 21.60 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 329 100.00 Very High Very High Very High
Metabolic Syndrome 117 100.00 Very High Very High Very High
Prediabetic State 84 100.00 Very High Very High Very High
Nicotine Addiction 76 100.00 Very High Very High Very High
Impaired Glucose Tolerance 48 99.80 Very High Very High Very High
Atherosclerotic Plaque 41 98.62 Very High Very High Very High
Cv Unclassified Under Development 15 98.08 Very High Very High Very High
Disease 87 96.40 Very High Very High Very High
Stress 97 96.24 Very High Very High Very High
Parkinson's Disease 2 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bao et al. [29] performed a metabonomic study to determine metabolic variations associated with T2DM and the drug treatments on 74 patients who were newly diagnosed with T2DM and received a 48-week treatment of a single drug, repaglinide, metformin, or rosiglitazone.
T2DM Binding (associated) of
1) Confidence 0.25 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2948926 Disease Relevance 0.39 Pain Relevance 0
The progression from IGT to frank DM2 is associated with an inability of the pancreatic beta cells to continue this excess secretion of insulin (Polonsky et al 1996; Roe et al 1996), however significant beta cell dysfunction may occur much earlier (DeFronzo 2004).
DM2 Binding (associated) of in beta cell associated with diabetes mellitus and tolerance
2) Confidence 0.17 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291335 Disease Relevance 1.45 Pain Relevance 0.21
We also used GSEA with our collection of gene-sets to compare DM2 and NGT in the diabetes data discussed above.
DM2 Binding (compare) of associated with diabetes mellitus and tolerance
3) Confidence 0.04 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1261155 Disease Relevance 0.72 Pain Relevance 0.05
Specifically, the pathway with the highest significance level, 'Activation of cAMP-dependent protein kinase, PKA (protein kinase A)' (Biocarta) was found in comparing DM2 and NGT (upregulated in DM2); the significance level, however, was calculated to be only p = 0.4.
DM2 Binding (comparing) of associated with diabetes mellitus and tolerance
4) Confidence 0.04 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1261155 Disease Relevance 1.34 Pain Relevance 0.36
MS, PD, and T2DM are associated with a diffuse endotheliopathy.
T2DM Binding (associated) of associated with diabetes mellitus, prediabetic state and metabolic syndrome
5) Confidence 0.02 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.66 Pain Relevance 0
MS, PD, and T2DM are associated with endothelial dysfunction and carry an elevated risk for both micro and macrovascular disease that are often present at the time of diagnosis of overt T2DM.
T2DM Binding (associated) of associated with diabetes mellitus, prediabetic state, metabolic syndrome and disease
6) Confidence 0.02 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 0.95 Pain Relevance 0.26
The atherosclerotic plaque angiogenic adventitial Vv within atheroscleropathy is excessive and associated with MS, PD, and overt T2DM.
T2DM Binding (associated) of in plaque associated with atherosclerotic plaque, diabetes mellitus, prediabetic state and metabolic syndrome
7) Confidence 0.01 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.67 Pain Relevance 0.27
This would certainly help to explain the earlier discussed atheroscleropathy associated with T2DM.
T2DM Binding (associated) of associated with diabetes mellitus
8) Confidence 0.01 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.46 Pain Relevance 0
This gene polymorphism then could interact with other gene polymorphisms and especially environmental conditions such as smoking, obesity, and the A-FLIGHT toxicities of IR, MS, PD, and overt T2DM.
T2DM Binding (interact) of associated with nicotine addiction, diabetes mellitus and metabolic syndrome
9) Confidence 0.00 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.37 Pain Relevance 0.09

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