INT173334

Context Info Confidence 0.03 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.05

cytosol (TPM2) cytoskeleton (TPM2) cytoplasm (TPM2)

Anatomy Link Frequency smooth muscle 2 TPM2 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 57 90.16 Kinase C 18 5.00 Inflammation 11 5.00 bradykinin 10 5.00 cytokine 8 5.00 adenocard 8 5.00 Catecholamine 3 5.00 antagonist 3 5.00 tolerance 2 5.00 Opioid 2 5.00

Disease Link Frequency Relevance Heat Starvation 1 68.16 Asthma 43 5.00 INFLAMMATION 12 5.00 Disease 10 5.00 Occupational Lung Diseases 9 5.00 Bronchospasm 2 5.00 Pressure And Volume Under Development 2 5.00 Necrosis 2 5.00 Airway Remodeling 2 5.00 Bordatella Infection 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, contractile function of cultured ASM cells is rapidly diminished, coinciding with reduced expression of smooth muscle alpha-actin and myosin heavy chain, calponin, h-caldesmon, beta-tropomyosin, and myosin light chain kinase (MLCK) [22].

Negative_regulation (reduced) of Gene_expression (expression) of beta-tropomyosin in smooth muscle

1) Confidence 0.03 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.07 Pain Relevance 0.05

General Comments

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