INT173430

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 9.38
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FLT4, VEGFA) cytoplasm (FLT4, VEGFA) extracellular space (VEGFA)
growth (VEGFA) proteinaceous extracellular matrix (VEGFA) plasma membrane (FLT4)
Anatomy Link Frequency
endothelial cells 3
lymph nodes 2
liver 1
endothelium 1
FLT4 (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 6 79.88 Quite High
cytokine 72 72.36 Quite High
Inflammation 73 52.40 Quite High
agonist 86 50.00 Quite Low
dexamethasone 26 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
fibrosis 11 5.00 Very Low Very Low Very Low
ischemia 8 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 515 100.00 Very High Very High Very High
Fibromyalgia 4 100.00 Very High Very High Very High
Metastasis 50 97.92 Very High Very High Very High
Lymphedema 290 97.60 Very High Very High Very High
Solid Tumor 60 94.40 High High
Pathologic Neovascularization 20 92.96 High High
Pressure And Volume Under Development 50 92.24 High High
Apoptosis 66 85.20 High High
Hypoxia 29 84.88 Quite High
Adenocarcinoma 7 82.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGFR-3, largely restricted to lymphatic endothelial cells, binds the VEGF homologues VEGF-C and VEGF-D and may play an important role in the regulation of lymphangiogenesis.
VEGFR-3 Binding (binds) of VEGF in endothelial cells
1) Confidence 0.25 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.41 Pain Relevance 0
VEGFR-3, largely restricted to lymphatic endothelial cells, binds the VEGF homologues VEGF-C and VEGF-D and may play an important role in the regulation of lymphangiogenesis.
VEGFR-3 Binding (binds) of VEGF in endothelial cells
2) Confidence 0.25 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.41 Pain Relevance 0
VEGFR-3, largely restricted to lymphatic endothelial cells, binds the VEGF homologues VEGF-C and VEGF-D and may play an important role in the regulation of lymphangiogenesis.
VEGFR-3 Binding (binds) of VEGF in endothelial cells
3) Confidence 0.25 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.41 Pain Relevance 0
VEGF has a key, rate-limiting role in promoting tumor angiogenesis and exerts its effects by binding to one of three tyrosine kinase receptors (Figure 1): VEGF receptor-1 (VEGFR-1; fms-like tyrosine kinase-1, Flt-1), VEGFR-2 (human kinase domain region, KDR/murine fetal liver kinase-1, Flk-1), and VEGFR-3 (Flt-4).
VEGFR-3 Binding (binding) of VEGF in liver associated with fibromyalgia and cancer
4) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.20 Pain Relevance 0.04
VEGFR-3 (Flt-4) is another VEGFR that binds to other members of the VEGF ligand family, VEGF-C and VEGF-D.
VEGFR-3 Binding (binds) of VEGF
5) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.86 Pain Relevance 0.03
VEGFR-3 (Flt-4) is another VEGFR that binds to other members of the VEGF ligand family, VEGF-C and VEGF-D.
VEGFR-3 Binding (binds) of VEGF
6) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.87 Pain Relevance 0.03
VEGFR-3 (Flt-4) is another VEGFR that binds to other members of the VEGF ligand family, VEGF-C and VEGF-D.
VEGFR-3 Binding (binds) of VEGF
7) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.86 Pain Relevance 0.03
This may be similar to what pertains in animal models in which inhibition of the binding of VEGF-C to membrane-bound VEGFR-3 by sVEGFR-3 led to complete destruction of the lymphatic network and a lymphedema-like phenotype [36].
VEGFR-3 Binding (binding) of VEGF associated with lymphedema
8) Confidence 0.03 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 1.03 Pain Relevance 0
VEGF-C and VEGF-D bind to VEGFR2 as well as VEGFR3 and are important for lymphangiogenesis and cancer metastasis to lymph nodes and spread through the lymphatic system [76–78].
VEGFR3 Binding (bind) of VEGF in lymph nodes associated with cancer and metastasis
9) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.76 Pain Relevance 0
VEGF-C and VEGF-D bind to VEGFR2 as well as VEGFR3 and are important for lymphangiogenesis and cancer metastasis to lymph nodes and spread through the lymphatic system [76–78].
VEGFR3 Binding (bind) of VEGF in lymph nodes associated with cancer and metastasis
10) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.76 Pain Relevance 0
There was also a positive association between levels of VEGF-C and antigenemia (r = 0.434, p < 0.0001) and between levels of sVEGFR-3 and antigenemia (r = 0.367, p = 0.0065), but no associations between microfilaremia and levels of VEGF-C (p = 0.8864) and sVEGFR-3 (p = 0.7720) were found.


sVEGFR-3 Neg (no) Binding (associations) of VEGF
11) Confidence 0.03 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 0.34 Pain Relevance 0
This may be similar to what pertains in animal models in which inhibition of the binding of VEGF-C to membrane-bound VEGFR-3 by sVEGFR-3 led to complete destruction of the lymphatic network and a lymphedema-like phenotype [36].
sVEGFR-3 Binding (binding) of VEGF associated with lymphedema
12) Confidence 0.03 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1564427 Disease Relevance 1.04 Pain Relevance 0
VEGF-C and D both act on VEGFR-3 (vascular endothelial growth factor receptor 3), which is a receptor for tyrosine kinase selectively expressed on lymphatic endothelium.
VEGFR-3 Binding (receptor) of vascular endothelial growth factor in endothelium
13) Confidence 0.02 Published 2003 Journal Filaria J Section Body Doc Link PMC153482 Disease Relevance 0.43 Pain Relevance 0.07

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