INT173591

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 35
Disease Relevance 3.65
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAMTS4) extracellular space (ADAMTS4) extracellular region (ADAMTS4)
proteinaceous extracellular matrix (ADAMTS4)
Anatomy Link Frequency
tendon 13
tendon cells 5
cartilage 1
ADAMTS4 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 326 100.00 Very High Very High Very High
Pain 429 99.32 Very High Very High Very High
cytokine 364 98.60 Very High Very High Very High
agonist 25 93.84 High High
Osteoarthritis 213 91.12 High High
Mechanotransduction 29 85.04 High High
rheumatoid arthritis 29 64.32 Quite High
Inflammation 29 5.00 Very Low Very Low Very Low
antagonist 22 5.00 Very Low Very Low Very Low
backache 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tendinopathy 291 99.00 Very High Very High Very High
Intervertebral Disk Degeneration 28 98.98 Very High Very High Very High
Necrosis 43 94.56 High High
Cancer 51 94.20 High High
Volume Depletion And Dehydration 4 93.96 High High
Osteoarthritis 214 91.12 High High
Disease 62 87.84 High High
Arthritis 22 83.92 Quite High
Disease Progression 8 80.40 Quite High
Rheumatoid Arthritis 29 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The principal change observed in the cellular expression of ADAMTS-4 protein in vitro was an increased level (of both main ADAMTS-4 forms) in cells stimulated by TGF-?
Gene_expression (expression) of ADAMTS-4
1) Confidence 0.48 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.09 Pain Relevance 0.12
None of these BMP stimulated ADAMTS-4 mRNA expression, compared with 10- to 30-fold stimulation by TGF-?
Gene_expression (expression) of ADAMTS-4 mRNA
2) Confidence 0.48 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.11 Pain Relevance 0.03
on ADAMTS-4 mRNA expression, measured after 16 h (Tzusaki et al., 2003): our work indicates that the optimum stimulation by IL-1?
Gene_expression (expression) of ADAMTS-4 mRNA
3) Confidence 0.48 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
Expression of ADAMTS-4 protein in tendon cells
Gene_expression (Expression) of ADAMTS-4 in tendon cells
4) Confidence 0.48 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
We noted previously (Jones et al., 2006) that ADAMTS-1 mRNA expression showed little variation between tendon tissue sample groups while ADAMTS-5 mRNA decreased in painful tendons, thus contrasting with the pattern of ADAMTS-4 mRNA expression.
Gene_expression (expression) of ADAMTS-4 mRNA in tendons associated with pain
5) Confidence 0.48 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.15
The activation of ADAMTS-4 expression thus shows a degree of specificity within the TGF-?
Gene_expression (expression) of ADAMTS-4
6) Confidence 0.48 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.10
Expression of ADAMTS-4 protein in tendon cells
Gene_expression (Expression) of ADAMTS-4 in tendon cells
7) Confidence 0.42 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
We found that placing tendon cells in a three-dimensional collagen gel (a version of the fibroblast-populated collagen lattice: Ehrlich and Rittenberg, 2000; Grinnell, 2003) increased the expression of ADAMTS-4 mRNA relative to the monolayer and decreased that of ADAMTS-1 and ADAMTS-5 (Table 1).
Gene_expression (expression) of ADAMTS-4 mRNA in tendon cells
8) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.12
The greatest stimulation of ADAMTS-4 mRNA expression by an individual growth factor or cytokine was induced by TGF-?
Gene_expression (expression) of ADAMTS-4 mRNA associated with cytokine
9) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.19 Pain Relevance 0.09
Regulation of ADAMTS-4 mRNA expression in cultured tendon cells
Gene_expression (expression) of ADAMTS-4 mRNA in tendon cells
10) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
We have now tested the effects of growth factors on the regulation of ADAMTS-4 mRNA expression in Achilles tendon-derived cells in both monolayer and three-dimensional collagen gel cultures, and examined the expression of ADAMTS-4 protein in tendon tissues and cells.


Gene_expression (expression) of ADAMTS-4 mRNA in tendon
11) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.12 Pain Relevance 0.24
We have now tested the effects of growth factors on the regulation of ADAMTS-4 mRNA expression in Achilles tendon-derived cells in both monolayer and three-dimensional collagen gel cultures, and examined the expression of ADAMTS-4 protein in tendon tissues and cells.


Spec (examined) Gene_expression (expression) of ADAMTS-4 in tendon
12) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.11 Pain Relevance 0.28
ADAMTS-4 mRNA was expressed at higher levels by tendon cells in collagen gels than in monolayer cultures.
Gene_expression (expressed) of ADAMTS-4 mRNA in tendon cells
13) Confidence 0.37 Published 2008 Journal Matrix Biol Section Abstract Doc Link PMC2443387 Disease Relevance 0.16 Pain Relevance 0.23
The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells
Gene_expression (expression) of ADAMTS-4 in tendon
14) Confidence 0.37 Published 2008 Journal Matrix Biol Section Title Doc Link PMC2443387 Disease Relevance 0.15 Pain Relevance 0.20
induced the largest stimulation of ADAMTS-4 mRNA expression by any individual growth factor, and co-addition of TGF-?
Gene_expression (expression) of ADAMTS-4 mRNA
15) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
stimulated ADAMTS-4 mRNA expression (typically 20-fold after 24 h), while interleukin-1 induced a smaller, shorter-term stimulation which synergised markedly with that induced by TGF-?.
Gene_expression (expression) of ADAMTS-4 mRNA
16) Confidence 0.37 Published 2008 Journal Matrix Biol Section Abstract Doc Link PMC2443387 Disease Relevance 0.18 Pain Relevance 0.25
Expression of ADAMTS-4 mRNA and protein in tendon tissue samples
Gene_expression (Expression) of ADAMTS-4 mRNA in tendon
17) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.05 Pain Relevance 0.23
Growth factors and cytokines, added to the cells after 48 h adaptation to serum-free medium, stimulated the expression of ADAMTS-4 mRNA, with different characteristic time-course and magnitude (Figs. 3 and 4).
Gene_expression (expression) of ADAMTS-4 mRNA associated with cytokine
18) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.14 Pain Relevance 0.07
The principal change observed in the cellular expression of ADAMTS-4 protein in vitro was an increased level (of both main ADAMTS-4 forms) in cells stimulated by TGF-?
Gene_expression (expression) of ADAMTS-4
19) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.09 Pain Relevance 0.12
induced substantially higher levels of ADAMTS-4 mRNA over the early period when IL-1?
Gene_expression (levels) of ADAMTS-4 mRNA
20) Confidence 0.37 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.15 Pain Relevance 0.07

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