INT173635

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.93
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (TFAP2A) nucleolus (TFAP2A) nucleus (TFAP2A)
cytoplasm (TFAP2A)
TFAP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 85 98.04 Very High Very High Very High
Inflammatory stimuli 4 60.76 Quite High
cINOD 2 29.20 Quite Low
Inflammatory response 17 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 101 100.00 Very High Very High Very High
INFLAMMATION 108 98.04 Very High Very High Very High
Cirrhosis 1 90.00 High High
Apoptosis 8 88.96 High High
Renal Cancer 55 87.32 High High
Reprotox - General 1 3 83.08 Quite High
Metastasis 7 82.28 Quite High
Adhesions 12 79.60 Quite High
Injury 2 72.96 Quite High
Hypoxia 7 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, loss of OXPHOS genes SLC25A5, ATP6V1B1, B3, V0A4, and NDUFA4 may contribute to the self-sufficiency of the cancer cells with the ability to be less dependent on OXPHOS (2) The loss of tumor suppressor genes PTPRO, TFAP2A, CDKN1C, AIM1 and MT1G as well as other genes that were shown to suppress tumor growth in cancer cell lines but not yet identified as tumor suppressor candidates (RASD1, VDR, EHF, SPP1, ACPP, MT1F and ERBB4) contributes to insensitivity to antigrowth signals; (3) Evasion of apoptosis is mediated through loss of SPP1 and SFRP1, and activation of TUBB, NOL3 and EGLN3. (4) Two groups of genes are likely to be involved in tissue invasion and metastasis: proteolysis genes (PAPPA, PSMB9 and MARCH-1) and genes involved in cell-adhesion and/or regulation of actin cytoskeleton (CNGLN, ITPR2, NPHS1, ITGB2, CLD1, ZAK, WASF2, CD81) and (5) Angiogenesis may be mediated through ALDOA enzyme which is shown to be activated by HIF1 under hypoxic conditions and by increased glycolytic activity (Warburg effect), and which in a feedback loop activates HIF1 (Lu et al. 2002) which then activates several angiogenic factors including VEGF.
Negative_regulation (loss) of TFAP2A associated with hypoxia, cancer, apoptosis, adhesions and metastasis
1) Confidence 0.34 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.68 Pain Relevance 0
For example, TFAP2A is inactivated [28] and SOX9 is inhibitive [29] in response to inflammation as shown in Figure 6.
Negative_regulation (inactivated) of TFAP2A associated with inflammation
2) Confidence 0.32 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.97 Pain Relevance 0.33
1 activation of p38 MAP kinase results in the inhibition of AP-2 DNA binding, resulting in increased expression of the aggrecan gene.
Negative_regulation (inhibition) of AP-2
3) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.28 Pain Relevance 0

General Comments

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