INT173788

Context Info Confidence 0.55 First Reported 2003 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 6 Disease Relevance 1.94 Pain Relevance 0.15

nucleus (Hoxa9) DNA binding (Hoxa9) cytoplasm (Hoxa9)

Anatomy Link Frequency duct 2 bone marrow 1 myeloid cells 1 hematopoietic cells 1 Hoxa9 (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 3 78.96 Sciatic nerve 3 71.96 Peripheral nerve injury 3 50.00 Neuropeptide 2 43.20 endometriosis 4 5.96 Central nervous system 16 5.00 Peripheral nervous system 9 5.00 anesthesia 8 5.00 Spinal cord 6 5.00 cva 4 5.00

Disease Link Frequency Relevance Heat Acute Myeloid Leukemia 16 99.30 Leukemia 20 97.46 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 87.72 Injury 9 84.68 Deafness 1 63.92 Congenital Anomalies 9 63.40 Syndrome 23 58.72 Nervous System Injury 4 50.00 Aplasia 4 44.16 Ovarian Cancer 4 7.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, HOXA7 [15], HOXA9 to HOXA13 [16], as well as HOXD9 to HOXD13 [17], are expressed along the differentiating Müllerian duct.

Gene_expression (expressed) of HOXA9 in duct

1) Confidence 0.55 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1444933 Disease Relevance 0.19 Pain Relevance 0

Studies demonstrated that MEIS1 gene and HOXA9-13 genes are co-expressed throughout Müllerian duct differentiation (Dintilhac et al., 2005), which suggests that MEIS1 might play a role in embryonic female genital tract development.

Gene_expression (expressed) of HOXA9 in duct

2) Confidence 0.41 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0

HOXA9 expression was found to cause transformation of normal hematopoietic cells to AML cells only when expressed together with MEIS1 (Kroon et al., 1998).

Gene_expression (expression) of HOXA9 in hematopoietic cells associated with acute myeloid leukemia

3) Confidence 0.41 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.53 Pain Relevance 0

Specifically, MEIS1 expression is vital for keeping HOXA9-immortalized myeloid cells in an undifferentiated, proliferating state, refractory to granulocyte-colony stimulating factor-induced terminal differentiation (Calvo et al., 2001).

Gene_expression (myeloid cells) of HOXA9-immortalized in myeloid cells

4) Confidence 0.35 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.51 Pain Relevance 0

Also in human leukemia, high expression of MEIS1 was found in bone marrow cells of acute myelogenous leukemia (AML) patients, where it was always co-expressed with HOXA9 (Smith et al., 1997; Lawrence et al., 1999).

Gene_expression (expressed) of HOXA9 in bone marrow associated with leukemia and acute myeloid leukemia

5) Confidence 0.35 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.53 Pain Relevance 0

In this context, the differential expression of homeobox-genes such as Hox-9 might recapitulate their role during embryonic ontogenesis.

Gene_expression (expression) of Hox-9

6) Confidence 0.09 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0.08 Pain Relevance 0.15

General Comments

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