INT173877

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Context Info
Confidence 0.08
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.83
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
fat pad 4
macrophages 2
osteoblasts 2
fibroblasts 2
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 22 100.00 Very High Very High Very High
Osteoarthritis 54 96.28 Very High Very High Very High
cytokine 99 95.56 Very High Very High Very High
isoflurane 35 94.48 High High
Inflammation 64 93.16 High High
substance P 104 87.16 High High
anesthesia 41 86.40 High High
cva 5 85.40 High High
dexamethasone 14 80.72 Quite High
adenocard 4 80.16 Quite High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 378 100.00 Very High Very High Very High
Metastasis 122 100.00 Very High Very High Very High
Infection 71 100.00 Very High Very High Very High
Phosphate Metabolism Disorders 55 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 24 100.00 Very High Very High Very High
Peripheral Arterial Disease 22 100.00 Very High Very High Very High
Osteoporosis 92 99.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 146 99.20 Very High Very High Very High
Intervertebral Disk Degeneration 44 97.60 Very High Very High Very High
Stress 50 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, mean IC50 OC values against H5N1 vary by viral clade and methodology, ranging from ?
Positive_regulation (ranging) of Gene_expression (vary) of In vitro
1) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.59 Pain Relevance 0
Therefore, the system specifications of the robotic workstation for automated in vitro selection were set to be as close as possible to the manual procedures.
Positive_regulation (automated) of Gene_expression (selection) of in vitro
2) Confidence 0.08 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.12
Process of automated in vitro selection
Positive_regulation (automated) of Gene_expression (selection) of in vitro
3) Confidence 0.08 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.04
In vitro cyclooxygenase gene expression in normal and HP fibroblasts exposed to pyridoxal phosphate (PLP) and calcium pyrophosphate (CPPD)
Positive_regulation (exposed) of Gene_expression (expression) of In vitro in fibroblasts associated with phosphate metabolism disorders
4) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.38 Pain Relevance 0
In vitro HCV infection in primary human macrophages resulted in increased TNF-?
Positive_regulation (resulted) of Gene_expression (infection) of In vitro in macrophages associated with hepatitis c virus infection and infection
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.54 Pain Relevance 0.06
The in vitro and in vivo aberrant immune activation and neurotoxicity mediated by HCV core protein were amplified in the presence of HIV-1 Vpr protein.
Positive_regulation (activation) of Gene_expression (amplified) of in vitro associated with drug induced neurotoxicity, acquired immune deficiency syndrome or hiv infection and hepatitis c virus infection
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 2.10 Pain Relevance 0.05
Whatever the cause, the formation of fibronectin fragments can then feed into the degenerative cascade because they have been shown to downregulate aggrecan synthesis but to upregulate the production of some MMPs in in vitro systems.
Positive_regulation (upregulate) of Gene_expression (production) of in vitro associated with metalloproteinase
7) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165040 Disease Relevance 0.34 Pain Relevance 0.14
[31] did not result in a net positive effect of conditioned serum on matrix metabolism in vitro, suggesting that, if any, in vivo effects of the TNF?
Neg (not) Positive_regulation (result) of Gene_expression (metabolism) of in vitro
8) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.39 Pain Relevance 0.33
Effect of bortezomib and glucocorticoid on osteoblast precursors and differentiated osteoblasts in vitro
Positive_regulation (differentiated) of Gene_expression (differentiated) of in vitro in osteoblasts associated with osteoporosis
9) Confidence 0.02 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.41 Pain Relevance 0.03
To test the effects of bortezomib and glucocorticoid treatment on undifferentiated or differentiated ADSCs, the cells were exposed during in vitro culture conditions to: (i) a 3-h pulse treatment with bortezomib 25 nm as described previously (39) and then placed in control medium, (ii) continuous exposure to 5 ?
Positive_regulation (during) of Gene_expression (exposed) of in vitro
10) Confidence 0.02 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.14 Pain Relevance 0.04
We believe that one of the reasons for the increase in intracerebral acetate levels was that propofol administration enhanced the in vivo production of acetate.
Positive_regulation (enhanced) of Gene_expression (production) of in vivo
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887427 Disease Relevance 0.09 Pain Relevance 0.31
The observation that there was no increase in the metastasis rate in the fat pad experiments in the Db-S line, despite increased OPN expression and the increased migration of the cells in vitro, was surprising.
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of in vitro in fat pad associated with peripheral arterial disease and metastasis
12) Confidence 0.01 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.57 Pain Relevance 0
The observation that there was no increase in the metastasis rate in the fat pad experiments in the Db-S line, despite increased OPN expression and the increased migration of the cells in vitro, was surprising.
Positive_regulation (increased) of Gene_expression (expression) of in vitro in fat pad associated with peripheral arterial disease and metastasis
13) Confidence 0.01 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.57 Pain Relevance 0
analog dramatically increased the in vitro production of PGF2?.
Positive_regulation (increased) of Gene_expression (production) of in vitro
14) Confidence 0.01 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293427 Disease Relevance 0 Pain Relevance 0
It stimulates ACTH production in vivo and in vitro (706, 708).
Positive_regulation (stimulates) of Gene_expression (production) of in vivo
15) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.72 Pain Relevance 0.15

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