INT173947

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, IGF1) extracellular region (Il6, IGF1) signal transduction (IGF1)
Il6 (Mus musculus)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 6 93.92 High High
rheumatoid arthritis 28 92.88 High High
Inflammation 4 90.60 High High
cytokine 13 16.08 Low Low
corticosteroid 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 98.28 Very High Very High Very High
Juvenile Chronic Polyarthritis 4 93.92 High High
Rheumatoid Arthritis 28 92.88 High High
Disease 7 90.96 High High
INFLAMMATION 6 90.60 High High
Osteoporosis 7 76.92 Quite High
Hyperplasia 1 70.24 Quite High
Endometriosis (extended) 6 69.28 Quite High
Rheumatic Diseases 3 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, De Benedetti and colleagues proposed that IL-6 mediated the decrease in IGF-1 production that was associated with growth defect in transgenic mice and they also showed that circulating IL-6 levels were negatively correlated with IGF-1 levels in JCA [33].
IL-6 Positive_regulation (mediated) of Gene_expression (production) of IGF-1 associated with targeted disruption and arthritis
1) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 1.02 Pain Relevance 0.31

General Comments

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