INT174439

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.24
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
neutrophils 2
T lymphocytes 2
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 68 100.00 Very High Very High Very High
cytokine 40 100.00 Very High Very High Very High
rheumatoid arthritis 204 99.64 Very High Very High Very High
Osteoarthritis 100 99.36 Very High Very High Very High
chemokine 66 79.56 Quite High
agonist 2 38.40 Quite Low
Crohn's disease 50 37.52 Quite Low
Arthritis 14 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 64 100.00 Very High Very High Very High
Colitis 138 99.88 Very High Very High Very High
Rheumatoid Arthritis 204 99.64 Very High Very High Very High
Osteoarthritis 100 99.36 Very High Very High Very High
Disease 104 80.40 Quite High
Inflammatory Bowel Disease 38 68.20 Quite High
Paratuberculosis 40 62.84 Quite High
Infection 6 26.08 Quite Low
Alzheimer's Dementia 4 7.20 Low Low
Body Weight 4 6.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Strong staining of MCs suggested a high density of CXCR3 antigen expression.
Regulation (density) of Gene_expression (expression) of CXCR3
1) Confidence 0.43 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.41 Pain Relevance 0.20
As with these innate immunity cells, neutrophils are compartmentalized in the MLN and tightly regulated to differentially express CXCL9 and CXCL11, CXCR3 and Th1-associated cytokines during Mycobacteria-mediated colitis.
Regulation (regulated) of Gene_expression (express) of CXCR3 in neutrophils associated with colitis and cytokine
2) Confidence 0.34 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.82 Pain Relevance 0.05
Alteration of DC cytokine and CXCR3 ligands expression following Mycobacteria challenge
Regulation (Alteration) of Gene_expression (expression) of CXCR3 associated with cytokine
3) Confidence 0.34 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.55 Pain Relevance 0.15
In order to consider the degree of differential infiltration of T lymphocytes as well as their influence on inflammation-induced CXCR3 expression between RA and OA, we analyzed the expression of TCR-?
Regulation (influence) of Spec (analyzed) Gene_expression (expression) of CXCR3 in T lymphocytes associated with inflammation, rheumatoid arthritis and osteoarthritis
4) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.47 Pain Relevance 0.77

General Comments

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