INT174658

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.54
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, ITGAM) signal transduction (TNF) extracellular space (TNF)
extracellular region (TNF) cell adhesion (ITGAM) intracellular (TNF)
Anatomy Link Frequency
polymorphonuclear neutrophils 2
TNF (Homo sapiens)
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 86.16 High High
Crohn's disease 1 80.16 Quite High
cytokine 1 80.00 Quite High
rheumatoid arthritis 1 78.56 Quite High
Infliximab 17 57.04 Quite High
Arthritis 4 8.72 Low Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 30 95.08 Very High Very High Very High
INFLAMMATION 6 86.16 High High
Necrosis 4 82.68 Quite High
Cancer 4 82.32 Quite High
Rheumatoid Arthritis 1 78.56 Quite High
Neurologic Manifestations 1 76.64 Quite High
Arthritis 7 74.32 Quite High
Retinal Vasculitis 1 73.16 Quite High
Uveitis 1 72.24 Quite High
Recurrence 3 49.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF-alpha and interleukin-8 might increase the expression of the CD11b-CD18 constitutively present on the polymorphonuclear neutrophils membrane and facilitate their rolling and diapedesis through the vascular endothelial wall [2,6].
TNF Spec (might) Positive_regulation (increase) of Gene_expression (expression) of CD11b in polymorphonuclear neutrophils
1) Confidence 0.16 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC194711 Disease Relevance 1.54 Pain Relevance 0.30

General Comments

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