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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.47
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr8) intracellular (Tlr8) DNA binding (Tlr8)
Anatomy Link Frequency
brain 1
neurite 1
Microglia 1
Tlr8 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 40 87.04 High High
Central nervous system 46 86.28 High High
chemokine 15 86.16 High High
Inflammation 19 71.20 Quite High
Hippocampus 10 65.48 Quite High
Substantia nigra 8 48.88 Quite Low
Dopamine 2 42.44 Quite Low
aspirin 2 35.68 Quite Low
Paracetamol 12 34.96 Quite Low
Glutamate 8 31.96 Quite Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 34 99.00 Very High Very High Very High
Apoptosis 10 95.56 Very High Very High Very High
Infection 12 88.64 High High
INFLAMMATION 33 71.20 Quite High
Fever 34 68.24 Quite High
Febrile Convulsions 1 60.00 Quite High
Coma 1 58.56 Quite High
Volume Depletion And Dehydration 1 57.92 Quite High
Heart Rate Under Development 1 53.92 Quite High
Disease 111 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR8 is dynamically expressed during mouse brain development and localizes to neurons and axons where it may regulate neurite outgrowth and apoptosis [53].
Gene_expression (expressed) of TLR8 in neurite associated with apoptosis
1) Confidence 0.39 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.49 Pain Relevance 0.03
Some TLRs are strongly expressed in the embryonic brain and TLR3 and TLR8 have been implicated in neurogenesis and neurite outgrowth in the developing brain whereas TLR2 and TLR4 have been shown to regulate adult neurogenesis [75, 76].
Gene_expression (expressed) of TLR8 in brain associated with neurodegenerative disease
2) Confidence 0.15 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.59 Pain Relevance 0.06
Microglia cells express mRNA for a wide range of TLR family members (TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8 and TLR9) much like other cells of the monocytic lineage [49].
Spec (like) Gene_expression (express) of TLR8 in Microglia
3) Confidence 0.13 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.39 Pain Relevance 0.13

General Comments

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