INT174686

Context Info Confidence 0.24 First Reported 2003 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.34 Pain Relevance 0.26

signal transduction (Tlr5) intracellular (Tlr5)

Anatomy Link Frequency Microglia 1 Tlr5 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 9 87.28 Central nervous system 4 86.28 cytokine 31 85.60 chemokine 14 84.72 agonist 2 75.76 fibrosis 1 55.32 Inflammation 9 38.24 aspirin 2 34.24 Paracetamol 12 33.52 vagus nerve 2 5.00

Disease Link Frequency Relevance Heat Infection 12 88.64 Cancer 82 88.40 Skin Cancer 8 82.96 Metastasis 46 78.40 Death 9 70.28 Experimental Melanoma 5 69.60 Fever 34 66.80 Febrile Convulsions 1 58.56 Coma 1 57.12 Volume Depletion And Dehydration 1 56.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

B16 cells also expressed other members of the TLR family including TLR1, TLR3, TLR5, TLR6 and TLR7 (Figure S1C).

Gene_expression (expressed) of TLR5

1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.96 Pain Relevance 0.13

Microglia cells express mRNA for a wide range of TLR family members (TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8 and TLR9) much like other cells of the monocytic lineage [49].

Spec (like) Gene_expression (express) of TLR5 in Microglia

2) Confidence 0.14 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.38 Pain Relevance 0.13

General Comments

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