INT174877

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Context Info
Confidence 0.04
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.97
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hras1) signal transduction (Hras1) Golgi apparatus (Hras1)
plasma membrane (Hras1) GTPase activity (Hras1)
Anatomy Link Frequency
intestines 1
kidney 1
Hras1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 63.84 Quite High
isoflurane 9 62.96 Quite High
ketamine 3 58.00 Quite High
anesthesia 3 53.40 Quite High
cINOD 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 18 98.36 Very High Very High Very High
Metabolic Disorder 3 92.72 High High
Congenital Anomalies 8 88.40 High High
Toxicity 1 84.80 Quite High
Ulcers 1 77.56 Quite High
Inflammatory Bowel Disease 2 64.60 Quite High
Celiac Disease 13 55.36 Quite High
INFLAMMATION 14 53.68 Quite High
Herpes Simplex Virus 3 16.88 Low Low
Disease 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gluten sensitization however, did not induce barrier dysfunction in C57Bl6 mice, emphasizing the relevance of the DQ8 transgene in the model (Figure S2).
Localization (relevance) of DQ8 transgene
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.57 Pain Relevance 0.06
As shown in the embryonic mouse, transgene protein is secreted within 72 hours, and highly significant quantities of the protein are readily apparent in the kidney.
Localization (secreted) of transgene protein in kidney
2) Confidence 0.02 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC239997 Disease Relevance 0.06 Pain Relevance 0.11
Infection of these cells with rAAV2 leads to a permanent population of cells producing and secreting the transgene protein.


Localization (secreting) of transgene protein associated with infection
3) Confidence 0.02 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC239997 Disease Relevance 0.19 Pain Relevance 0.03
The high resolution, 3-dimensional, deconvoluting microscopy analysis of NHP intestines at 15 months of age (16 months post-therapy) demonstrated that epithelial cells of the intestines are secreting the transgene protein into the lacteal for lymphatic drainage into the general circulation via the thoracic duct.
Localization (secreting) of transgene protein in intestines
4) Confidence 0.02 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC239997 Disease Relevance 0.15 Pain Relevance 0

General Comments

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