INT175222

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Context Info
Confidence 0.02
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UBC) nucleoplasm (UBC) plasma membrane (UBC)
nucleus (UBC) cytoplasm (UBC)
Anatomy Link Frequency
K48 2
UBC (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 7 15.60 Low Low
Neuritis 14 11.04 Low Low
Eae 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 35 81.12 Quite High
Neurodegenerative Disease 28 80.64 Quite High
Disease 91 71.88 Quite High
Neurological Disease 7 67.92 Quite High
Autoimmune Disease 7 57.12 Quite High
Organ Transplantation 7 55.64 Quite High
Neuritis 14 11.04 Low Low
Alzheimer's Dementia 28 5.00 Very Low Very Low Very Low
Amyloid Plaque 21 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to understand whether the proteins identified in our screen bind to the p62’s UBA domain through lysine 48 (K48), polyubiquitin K48 chains were added to the p62 UBA pull down assay (Fig. 6).
polyubiquitin Binding (bind) of in K48
1) Confidence 0.02 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.33 Pain Relevance 0
Our results revealed that HSP70 utilizes K63 linkage to assemble polyubiquitin chains to bind to p62’s UBA domain since only the K63R ubiquitin mutant blocked the ubiquitination of HSP70 (Fig. 8A).
polyubiquitin Binding (bind) of
2) Confidence 0.02 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0
Interestingly, proteins with UBA domains are more
likely to bind polyubiquitin chains over monoubiquitin, such as the yeast UBA
protein Rad23, a highly conserved protein involved in nucleotide excision
repair (13). 
polyubiquitin Spec (likely) Binding (bind) of
3) Confidence 0.02 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0
The UBA domain is a conserved sequence motif among proteins that can
bind polyubiquitin. 
polyubiquitin Binding (bind) of
4) Confidence 0.02 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0
The specific type of polyubiquitin chain recognized by p62’s UBA domain is not yet known and studies are underway lab to determine p62’s interaction with specific polyubiquitin chains, however, our preliminary studies suggest that p62’s UBA domain may recognize K63 linked polyubiquitin chains.
polyubiquitin Binding (recognize) of
5) Confidence 0.02 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.12 Pain Relevance 0
The specific type of polyubiquitin chain recognized by p62’s UBA domain is not yet known and studies are underway lab to determine p62’s interaction with specific polyubiquitin chains, however, our preliminary studies suggest that p62’s UBA domain may recognize K63 linked polyubiquitin chains.
polyubiquitin Binding (recognized) of
6) Confidence 0.02 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0
Out of the five proteins, four proteins (# 2, 3, 4, and 5) showed reduced binding ability with p62’s UBA domain when polyubiquitin K48 chains were included (Fig. 6A, 6B).
polyubiquitin Binding (binding) of in K48
7) Confidence 0.02 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.08 Pain Relevance 0

General Comments

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