INT175303

Context Info Confidence 0.10 First Reported 2003 Last Reported 2003 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 6 Disease Relevance 5.19 Pain Relevance 1.52

extracellular space (Pnlip) extracellular region (Pnlip) lipid metabolic process (Pnlip)

Pnlip (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 204 98.56 Inflammation 60 94.64 alcohol 6 93.36 agonist 60 88.96 antagonist 6 83.52 metalloproteinase 102 81.68 Dismenorea 6 53.52 chemokine 18 44.72 cva 12 5.00 withdrawal 6 5.00

Disease Link Frequency Relevance Heat Pre-term Labor 240 100.00 Infection 66 99.90 INFLAMMATION 72 94.64 Premature Birth 54 91.92 Pre-eclampsia 6 90.12 Fetal Death 12 88.64 Apoptosis 18 88.32 Bacterial Respiratory Disease 12 84.60 Cerebral Palsy 12 80.08 Periventricular Leukomalacia 6 78.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This result is surprising, because C3H/HeJ mice, which that lack a functional TLR4, are resistant to PTL induced by E. coli [138,139].

Positive_regulation (induced) of PTL associated with pre-term labor

1) Confidence 0.10 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.72 Pain Relevance 0.16

These molecules may be excellent targets for therapeutic strategies because they are upstream mediators of the proinflammatory cascade that ultimately results in PTL.

Positive_regulation (results) of PTL associated with pre-term labor

2) Confidence 0.10 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.52 Pain Relevance 0.30

-induced PTL in rhesus monkeys, indicating that IL-10 may function at steps downstream from IL-1?

Positive_regulation (induced) of PTL associated with pre-term labor

3) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.82 Pain Relevance 0.07

Furthermore, inhibitors of cyclooxygenases and nitric oxide synthases (iNOS) block LPS-induced PTL in mice [114-116].

Positive_regulation (induced) of PTL associated with pre-term labor

4) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.76 Pain Relevance 0.33

was able to mimic the effects of bacteria by causing PTL, suggesting a causal role for this cytokine in infection-induced PTL [106,107].

Positive_regulation (causing) of PTL associated with pre-term labor, infection and cytokine

5) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 1.10 Pain Relevance 0.38

Infection may cause PPROM and PTL by causing a premature activation of cytokine cascades that in turn, activate the parturition mechanisms described above.

Spec (may) Positive_regulation (cause) of PTL associated with pre-term labor, infection and cytokine

6) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 1.28 Pain Relevance 0.28

General Comments

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