INT175515

Context Info Confidence 0.08 First Reported 2003 Last Reported 2003 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.69 Pain Relevance 0

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad) mitochondrion (Bad) cytoplasm (Bad)

Bad (Mus musculus)

Pain Link Frequency Relevance Heat Bile 2 5.00 palliative 2 5.00 metalloproteinase 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 78 99.16 Death 14 94.92 Cancer 144 73.48 Liver Cancer 24 62.80 Hepatocellular Cancer 72 50.00 Metastasis 8 18.60 Severe Combined Immunodeficiency 14 5.00 Cirrhosis 10 5.00 Disease 8 5.00 Cleidocranial Dysplasia 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using anti-phospho-specific Bad (Ser122) and Bad (Ser136) antibodies, we observed that blocking MEK1/2 activity did not alter the levels of Bad phosphorylation at Serine 112 and Serine 136 (data not shown).

Neg (not) Regulation (alter) of Phosphorylation (phosphorylation) of Bad

1) Confidence 0.08 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.84 Pain Relevance 0

Therefore, it is unlikely that alterations of Bcl-2 family of proteins or phosphorylation of Bad are responsible for apoptosis seen in HepG2 and Hep3B cells following U0126 treatment.

Regulation (alterations) of Phosphorylation (phosphorylation) of Bad associated with apoptosis

2) Confidence 0.08 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.85 Pain Relevance 0

General Comments

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