INT175517

From wiki-pain
Revision as of 18:10, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2003
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 16.28
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mdm2) intracellular (Mdm2) enzyme binding (Mdm2)
protein complex assembly (Mdm2) protein complex (Mdm2) ligase activity (Mdm2)
Anatomy Link Frequency
hepatocyte 1
Mdm2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 100.00 Very High Very High Very High
palliative 2 79.48 Quite High
Pain 17 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoma 289 99.76 Very High Very High Very High
Viral Infection 1 99.64 Very High Very High Very High
Cancer 672 99.60 Very High Very High Very High
Metastasis 329 99.20 Very High Very High Very High
Liposarcoma 408 97.96 Very High Very High Very High
Recurrence 341 97.28 Very High Very High Very High
Infection 35 96.72 Very High Very High Very High
Nervous System Injury 17 95.80 Very High Very High Very High
Malignant Neoplastic Disease 75 95.66 Very High Very High Very High
Injury 51 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical evidence of the presence or absence of MDM2 gene expression did not reach statistically significant levels and was not considered a prognostic factor for metastasis-free survival.


Gene_expression (expression) of MDM2 associated with metastasis
1) Confidence 0.78 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.58 Pain Relevance 0
1) There was no correlation between the MDM2 protein expression as observed by immunohistochemistry and the anatomical and pathological variables studied; additionally, there was no relationship between those variables and the different prognostic factors in primary liposarcomas of the extremities. 2) Factors such as male sex, pleomorphic histological subtype, and high grade of malignancy are unfavorable for local recurrence-free survival. 3) Factors such as male sex, age under 50 years, pleomorphic subtype, and high histological grade are adverse for metastasis-free survival and overall survival. 4) MDM2 expression was a frequent event in the different subtypes of liposarcomas.



Gene_expression (expression) of MDM2 protein associated with liposarcoma, malignant neoplastic disease, metastasis and recurrence
2) Confidence 0.78 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.77 Pain Relevance 0
1) There was no correlation between the MDM2 protein expression as observed by immunohistochemistry and the anatomical and pathological variables studied; additionally, there was no relationship between those variables and the different prognostic factors in primary liposarcomas of the extremities. 2) Factors such as male sex, pleomorphic histological subtype, and high grade of malignancy are unfavorable for local recurrence-free survival. 3) Factors such as male sex, age under 50 years, pleomorphic subtype, and high histological grade are adverse for metastasis-free survival and overall survival. 4) MDM2 expression was a frequent event in the different subtypes of liposarcomas.



Gene_expression (expression) of MDM2 associated with liposarcoma, malignant neoplastic disease, metastasis and recurrence
3) Confidence 0.78 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.62 Pain Relevance 0
The product of MDM2 interacts with the p53 protein and inhibits its ability to regulate genetic expression as a transcription factor.
Gene_expression (product) of MDM2
4) Confidence 0.78 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 1.12 Pain Relevance 0
The objective of this study, which is part of a general survey on sarcomas,16 was to investigate MDM2 protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival, and overall survival in patients with primary liposarcomas of the extremities.


Spec (investigate) Gene_expression (expression) of MDM2 protein associated with liposarcoma, sarcoma, metastasis and recurrence
5) Confidence 0.78 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.95 Pain Relevance 0
To study the MDM2 nuclear expression marker, we selected the cases for which specimens had been preserved in paraffin blocks at the time of biopsy prior to any adjuvant therapy, and only primary tumors were included.


Gene_expression (expression) of MDM2 associated with cancer
6) Confidence 0.68 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 1.23 Pain Relevance 0
In our case series, immunohistochemistry showed MDM2 protein expression in 22 (88%) of the 25 cases.
Gene_expression (expression) of MDM2 protein
7) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.71 Pain Relevance 0
The changes in the MDM2 gene are known to be a common mechanism in the genesis of liposarcomas.31 The amplification of this gene and its mRNA overexpression can lead to overproduction of MDM2 protein.32 The immunohistochemical analysis reveals nuclear location and overexpression of MDM2 in these tumors with amplification of the MDM2 gene.33
Gene_expression (overexpression) of MDM2 associated with liposarcoma and cancer
8) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 1.07 Pain Relevance 0
As shown in Table 3, there was no statistically significant association between the expression (or not) of MDM2 protein and the following anatomical and pathological variables: subtype, grade, and size of tumors.


Gene_expression (expression) of MDM2 protein associated with cancer
9) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.64 Pain Relevance 0
There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied.
Gene_expression (expressions) of MDM2 protein
10) Confidence 0.60 Published 2008 Journal Clinics Section Abstract Doc Link PMC2664204 Disease Relevance 0.63 Pain Relevance 0
The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities.


Spec (investigate) Gene_expression (expression) of MDM2 associated with liposarcoma, metastasis and recurrence
11) Confidence 0.60 Published 2008 Journal Clinics Section Abstract Doc Link PMC2664204 Disease Relevance 0.51 Pain Relevance 0
The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas.



Gene_expression (immunoexpression) of MDM2 protein associated with liposarcoma
12) Confidence 0.60 Published 2008 Journal Clinics Section Abstract Doc Link PMC2664204 Disease Relevance 0.54 Pain Relevance 0
Also, the presence or absence of MDM2 protein expression did not influence the overall survival.


Gene_expression (expression) of MDM2 protein
13) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.45 Pain Relevance 0
Analysis of the correlation between MDM2 protein expression and anatomical and pathological variables
Gene_expression (expression) of MDM2 protein
14) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.57 Pain Relevance 0
Although immunohistochemistry can be used to demonstrate MDM2 overexpression, direct correlation between the gene amplification and protein overexpression is not the rule.35 Nevertheless, mutations cause an irregular increase in stable proteins that can be detected by immunohistochemistry.36
Gene_expression (overexpression) of MDM2
15) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 0.77 Pain Relevance 0
Of the 25 cases evaluated for MDM2 protein expression, 22 (88%) presented positive indexes (?
Gene_expression (expression) of MDM2 protein
16) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 1.28 Pain Relevance 0
The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival).
Gene_expression (expression) of MDM2 protein associated with metastasis and recurrence
17) Confidence 0.60 Published 2008 Journal Clinics Section Abstract Doc Link PMC2664204 Disease Relevance 0.58 Pain Relevance 0
In support of this concept are data demonstrating that a polymorphism in the promoter region of the MDM2 gene enhances MDM2 expression, attenuates p53 tumor suppressor function and accelerates tumor progression rates of both hereditary and sporadic human cancers arising in the context of p53 alterations [35].


Gene_expression (expression) of MDM2 associated with cancer
18) Confidence 0.44 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.76 Pain Relevance 0
While approximately half of all human tumors contain a mutation or deletion of TP53, the rest of the tumors often have inactivation of p53 through other mechanisms including viral infection, loss of ARF, or overexpression of MDM2 [21].
Gene_expression (overexpression) of MDM2 associated with cancer and viral infection
19) Confidence 0.25 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.34 Pain Relevance 0
, hepatocyte growth factor and c-met, c-ErbB-2, u-plasminogen activator, MXR7, MDM2, MAGE, matrix metalloproteinase, Smads, p53, pRB, p16INK4, p21WAF1/CIP1, p27Kip1, PTEN, E-cadherin, ?
Gene_expression (/) of MDM2 in hepatocyte associated with metalloproteinase
20) Confidence 0.07 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.17 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox