INT175655

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.96
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
macrophages 1
chondrocyte 1
extracellular matrix 1
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 103 99.84 Very High Very High Very High
Inflammatory response 9 97.68 Very High Very High Very High
metalloproteinase 69 97.20 Very High Very High Very High
diclofenac 34 93.08 High High
fibrosis 19 91.80 High High
Inflammation 54 91.60 High High
Kinase C 3 91.20 High High
Osteoarthritis 44 85.36 High High
Central nervous system 16 85.36 High High
Infliximab 40 75.36 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 24 99.80 Very High Very High Very High
Uterine Fibroids 240 99.68 Very High Very High Very High
Death 14 99.22 Very High Very High Very High
Hepatitis C Virus Infection 54 98.56 Very High Very High Very High
INFLAMMATION 68 97.50 Very High Very High Very High
Prostate Cancer 87 97.48 Very High Very High Very High
Apoptosis 51 97.30 Very High Very High Very High
Adhesions 172 96.88 Very High Very High Very High
Asthma 2 96.88 Very High Very High Very High
Pulmonary Disease 99 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence and significance of macrophages infiltration in developing neoplasms is now well recognized, and infiltrating macrophages play an important role in tumor cell invasion into surrounding normal tissues [24,25], including expression of growth factors, matrix proteases, promotion of angiogenesis and suppression of adaptive immunity, all of which influence the ECM and hypoxia, two non-cellular components that potently influence stromal-epithelial interactions [21,26] (Figure 1).
Regulation (influence) of ECM in macrophages associated with hypoxia and cancer
1) Confidence 0.12 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.99 Pain Relevance 0.13
Consequently, the process of adhesion formation include inflammatory response, fibrin deposition, cell-proliferation, -differentiation, -migration, -death, angiogenesis, extra cellular matrix (ECM) turnover regulated by cytokines, hypoxia, genetic and epigenetic factors [3].
Regulation (regulated) of ECM associated with inflammatory response, hypoxia, death, adhesions and cytokine
2) Confidence 0.11 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.32 Pain Relevance 0.17
regulation of ECM proteins such as collagens23 and fibronectin,26,27,29 and has also been demonstrated.
Regulation (regulation) of ECM
3) Confidence 0.11 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.53 Pain Relevance 0.10
was able to modulate ECM turnover by inhibition of protein synthesis and activation of matrix metalloproteinases.
Regulation (modulate) of ECM associated with metalloproteinase
4) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.09 Pain Relevance 0.26
-induced effects on cell proliferation (Figure 4), ECM contraction (Figure 5b), and collagen type I gene expression (Figure 6b).
Regulation (effects) of ECM
5) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0 Pain Relevance 0.35
The mechanism of ATRA in leiomyoma cells that results in ECM regulation remain speculative.
Regulation (regulation) of ECM associated with uterine fibroids
6) Confidence 0.05 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.65 Pain Relevance 0.13
Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer

Prostate cancer (PCa) is no exception to the multi-step process of metastasis.

Regulation (Changes) of ECM in extracellular matrix associated with prostate cancer and metastasis
7) Confidence 0.05 Published 2004 Journal Reprod Biol Endocrinol Section Title Doc Link PMC320496 Disease Relevance 1.24 Pain Relevance 0
As BMP-7 has been shown to prevent NP cell apoptosis [50] and stimulation with recombinant BMP-7 is known to enhance PG production by NP cells [51], SOSTDC1 may play an important role in regulating ECM homeostasis and cell number within the IVD.
Regulation (regulating) of ECM associated with apoptosis
8) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.10 Pain Relevance 0
Furthermore, vibratory loading has been associated with the activation of signalling pathways that regulate ECM destruction in the IVD [127].
Regulation (regulate) of ECM
9) Confidence 0.04 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0.67 Pain Relevance 0.08
Lastly, cyclic tensile stretch was found to regulate the ECM by decreasing proteoglycan production through a post-translational regulation involving nitrite oxide [92].
Regulation (regulate) of ECM
10) Confidence 0.04 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0.73 Pain Relevance 0.07
This effect, but also the effects on ECM elaboration and organization, was more pronounced in the scaffold seeded with outer AF cells [93].
Regulation (effects) of ECM
11) Confidence 0.04 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0.07 Pain Relevance 0
The net effect on ECM metabolism is based on the relative ratios of MMP and TIMP.
Regulation (effect) of ECM
12) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.09 Pain Relevance 0.03
Thus, altered ECM deposition contributing to airway wall remodeling is an important feature of asthma and COPD.
Regulation (altered) of ECM associated with asthma and pulmonary disease
13) Confidence 0.02 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 0.72 Pain Relevance 0.18
These properties of ECM are tightly regulated by a family of mostly Ca2+-dependent Zn2+-containing endopeptidases (MMPs) [11,12].
Regulation (regulated) of ECM
14) Confidence 0.02 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.89 Pain Relevance 0.16
These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [4].
Regulation (regulated) of ECM in chondrocyte
15) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 1.03 Pain Relevance 0.46
Similarly, no significant changes in ECM were detected within the untreated HCV cohort (for genotype 1: 29.0 ± 2.2 l at baseline versus 27.2 ± 3.0 l after 48 weeks and for genotype 3: 27.8 ± 2.5 l at baseline versus 27.4 ± 2.4 l after 24 weeks; p > 0.05).


Regulation (changes) of ECM associated with hepatitis c virus infection
16) Confidence 0.02 Published 2010 Journal Virol J Section Body Doc Link PMC2930625 Disease Relevance 0.84 Pain Relevance 0

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