INT175794

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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.82
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
thyroid 2
pituitary 2
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 81 96.68 Very High Very High Very High
substance P 5 87.68 High High
Morphine 4 85.72 High High
agonist 5 85.36 High High
Neuropeptide 8 85.04 High High
Opioid 5 84.68 Quite High
Inflammation 67 81.92 Quite High
Osteoarthritis 1 78.04 Quite High
Peripheral nervous system 3 66.60 Quite High
amygdala 9 57.20 Quite High
Disease Link Frequency Relevance Heat
Stress 69 97.08 Very High Very High Very High
Rheumatoid Arthritis 81 96.68 Very High Very High Very High
INFLAMMATION 71 81.92 Quite High
Osteoarthritis 1 78.04 Quite High
Cognitive Disorder 1 60.88 Quite High
Disease 27 36.96 Quite Low
Arthritis 18 11.52 Low Low
Hypersensitivity 11 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Autoimmune Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whilst changes in pituitary drive between D16 and D19 may partly account for the reduced HPA response, the present data clearly show that there is also a marked reduction in stress-induced activation of the PVN.
Negative_regulation (reduced) of Gene_expression (response) of HPA in pituitary associated with stress
1) Confidence 0.12 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.67 Pain Relevance 0.03
However, these studies have generally shown a defect in cortisol secretion after HPA axis stimulation, decreased androgen levels, a blunted GH response, and dysregulation of the thyroid response.
Negative_regulation (blunted) of Gene_expression (response) of HPA in thyroid
2) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.15 Pain Relevance 1.05

General Comments

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