INT175892

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PKD1) nucleus (PKD1) cilium (PKD1)
cytoplasm (PKD1)
PKD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 99.96 Very High Very High Very High
Disease 42 93.80 High High
Cancer 10 87.36 High High
Cyst 24 85.20 High High
Apoptosis 32 75.04 Quite High
Polycystic Kidney Disease 42 53.32 Quite High
Chronic Renal Failure 12 22.72 Low Low
Renal Disease 3 22.48 Low Low
Autosomal Dominant Polycystic Kidney 23 15.52 Low Low
Cystic Kidney Diseases 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The methods successfully developed for mutation analysis of this gene are based on discrimination of PKD1 from the non-functional homologous genes, by enrichment of PKD1 sequence while suppressing the homologous ones to undetectable levels.
Negative_regulation (discrimination) of PKD1
1) Confidence 0.42 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.22 Pain Relevance 0
While these investigators also showed that p21 levels were reduced in Pkd1 knockout mice, there has to our knowledge been no published study examining the function of p21 in human tissues or in non-knockout animal models of this disease.
Negative_regulation (reduced) of Pkd1 associated with targeted disruption and disease
2) Confidence 0.30 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.81 Pain Relevance 0

General Comments

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