INT175910

Context Info Confidence 0.06 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.01 Pain Relevance 0.22

extracellular space (SERPINE1, PLAU) extracellular region (SERPINE1, PLAU) plasma membrane (SERPINE1, PLAU) peptidase activity (PLAU) signal transduction (PLAU)

SERPINE1 (Homo sapiens) PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 6 91.68 Inflammation 31 65.40 chemokine 1 64.04 cytokine 3 63.56 ischemia 5 44.24 cva 19 16.52 Tetrahydrobiopterin 6 5.00 Inflammatory response 4 5.00 chest pain 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 38 98.20 Prediabetic State 24 97.80 Metabolic Syndrome 31 97.64 INFLAMMATION 35 65.40 Thrombosis 3 54.76 Coronary Vasospasm 1 54.20 Stress 19 50.96 Malignant Neoplastic Disease 13 50.00 Cv Unclassified Under Development 5 44.24 Increased Venous Pressure Under Development 6 35.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PAI-1 inhibits both tissue and urokinase plasminogen activator resulting in impaired synthesis of plasmin.

PAI-1 Negative_regulation (inhibits) of urokinase plasminogen activator

1) Confidence 0.06 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.01 Pain Relevance 0.22

General Comments

This test has worked.