INT17598

Context Info Confidence 0.50 First Reported 1991 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 12 Disease Relevance 2.60 Pain Relevance 2.38

extracellular space (CFHR1) extracellular region (CFHR1)

Anatomy Link Frequency forelimb 1 amniotic fluid 1 body 1 CFHR1 (Homo sapiens)

Pain Link Frequency Relevance Heat narcan 14 99.68 Morphine 8 98.96 Dismenorea 32 94.88 analgesia 9 87.88 epidural 7 86.96 Opioid 4 81.60 Peripheral nervous system 1 81.44 antagonist 4 81.04 cva 6 65.08 headache 4 5.00

Disease Link Frequency Relevance Heat Hypertension 2 100.00 Cv Unclassified Under Development 24 99.60 Dysmenorrhea 34 94.88 Oligohydramnios 2 86.72 Eclampsia 2 81.20 Hypersensitivity 4 75.88 Recurrence 4 75.84 Disease 18 75.40 Diabetes Mellitus 1 71.28 Cv General 3 Under Development 6 65.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We hypothesised that the crossover responsible for deletion of CFHL1 could also potentially result in formation of a CFH/CFHL1 hybrid gene.

Positive_regulation (formation) of CFHL1

1) Confidence 0.50 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.23 Pain Relevance 0

This was expected, because the hybrid CFH/CFHL1 gene described here would not be picked up by genomic sequencing using CFH-specific primers CFH cDNA Sequencing

Positive_regulation (hybrid) of CFHL1

2) Confidence 0.50 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.14 Pain Relevance 0

Morphine administration significantly decreased FHR, but it increased FHR variation and forelimb movements (LM).

Positive_regulation (increased) of FHR in forelimb associated with morphine

3) Confidence 0.44 Published 2001 Journal J. Appl. Physiol. Section Abstract Doc Link 11247963 Disease Relevance 0 Pain Relevance 0.70

Naloxone administration increased gross body movements and FHR without significant changes in FHR variation.

Positive_regulation (increased) of FHR in body associated with narcan

4) Confidence 0.39 Published 2001 Journal J. Appl. Physiol. Section Abstract Doc Link 11247963 Disease Relevance 0 Pain Relevance 0.74

There was an increase in FHR variation during labor averaging 40%.

Positive_regulation (increase) of FHR

5) Confidence 0.38 Published 1991 Journal Obstet Gynecol Section Abstract Doc Link 1923162 Disease Relevance 0 Pain Relevance 0.13

Peptides of the 55-kDa protein were identified as fragments of CFHR5 and tryptic peptides of the 37- and 32-kDa protein represented CFHR1?

Positive_regulation (represented) of CFHR1

6) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0 Pain Relevance 0

After washing, equimolar amounts (33 µM) of CFH, CFHR1, CFHR2 or CFHR5 were added and incubated for 1 h at RT.

Positive_regulation (incubated) of CFHR1

7) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0 Pain Relevance 0

This can be easily explained, since the obstetrician is fully dependent on indirectly collected information regarding the fetal condition, such as (a) movements experienced by the mother, observed with ultrasound or recorded with kinetocardiotocography (Schmidt, 1994), (b) perfusion of various vessels, as assessed by Doppler velocimetry, (c) the amount of amniotic fluid or (d) changes reflected in the condition of the mother, such as the development of gestation-induced hypertension and (e) the easily, continuously obtainable FHR signal.

Positive_regulation (dependent) of FHR in amniotic fluid associated with hypertension

8) Confidence 0.33 Published 1996 Journal Baillieres Clin Obstet Gynaecol Section Abstract Doc Link 8836480 Disease Relevance 0.10 Pain Relevance 0.04

Results mainly show a general, statistically significant (t test, p<0.01) power increase of the FHR variability in the LF 0.03-0.2 Hz and HF 0.2-1 in correspondence of the contraction with respect to a reference tract set before contraction onset.

Positive_regulation (increase) of FHR

9) Confidence 0.13 Published 2006 Journal Med Biol Eng Comput Section Abstract Doc Link 16937160 Disease Relevance 0.39 Pain Relevance 0.39

This allows increasing the “equivalent” FHR sampling frequency up to 2 Hz.

Positive_regulation (increasing) of FHR

10) Confidence 0.02 Published 2009 Journal Med Biol Eng Comput Section Body Doc Link PMC2734261 Disease Relevance 0.14 Pain Relevance 0

Ephedrine increases the FHR[18] when used during labour.

Positive_regulation (increases) of FHR

11) Confidence 0.01 Published 2010 Journal Indian Journal of Anaesthesia Section Body Doc Link PMC2991648 Disease Relevance 0.82 Pain Relevance 0.20

The foetal cardiac output depends on FHR, and therefore, in the situation of foetal bradycardia, the benefit of an increase in FHR is likely to outweigh the deleterious metabolic effects of Ephedrine.

Positive_regulation (increase) of FHR associated with cv unclassified under development

12) Confidence 0.01 Published 2010 Journal Indian Journal of Anaesthesia Section Body Doc Link PMC2991648 Disease Relevance 0.78 Pain Relevance 0.18

General Comments

This test has worked.