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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.31
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdk2) cytoplasm (Cdk2) cytosol (Cdk2)
mitosis (Cdk2) nucleus (Cdk2) cytoskeleton (Cdk2)
Anatomy Link Frequency
crypt cells 1
intestine 1
Cdk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 52 96.32 Very High Very High Very High
Crohn's disease 3 72.92 Quite High
Hippocampus 21 37.68 Quite Low
alcohol 3 17.84 Low Low
ischemia 2 14.56 Low Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 134 98.44 Very High Very High Very High
Retinoblastoma 4 95.20 Very High Very High Very High
Disease 82 92.64 High High
Hepatocellular Cancer 78 88.80 High High
Adenocarcinoma 1 88.60 High High
Colon Cancer 4 87.16 High High
Cancer 94 86.56 High High
Obesity 6 80.44 Quite High
Infection 29 78.88 Quite High
Tauopathy 80 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CDK2, CDK4, and CDK6 are the active kinases controlling G1/S transition in mammals.
Regulation (controlling) of CDK2
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
CCNA1 belongs to the cyclin family, and binds to important cell cycle regulators such as E2F, Rb, CDK2 and p21, but its abundance in the intestine is low [34].
Regulation (regulators) of CDK2 in intestine
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0.39 Pain Relevance 0.04
Taken together, our data suggest that in mouse intestinal crypt cells, miR-103 is part of the G1/S transition regulatory network, which targets CCNE1, CDK2, and CREB1 during IGF-1 stimulated proliferation.



Regulation (targets) of CDK2 in crypt cells
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
Conversely, cell-cycle inhibitor p27KIP1 was strongly down-regulated, while markers like Ki67 and cdk2 were hardly affected by tau-mediated neurodegeneration (Figure 8A; results not shown).
Regulation (affected) of cdk2
4) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.30 Pain Relevance 0.03
In summary, we identified important genes that are altered at the transcriptional level by E6 in our model, in particular the uncoupling of cell cycle regulation (cdc2, cyclin B, cdk2 and cyclin E), down-regulation of pro-apoptotic genes (Fas) and up-regulation of anti-apoptotic genes (Birc5).
Regulation (regulation) of cdk2 associated with apoptosis
5) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.43 Pain Relevance 0
It is likely therefore, that the induction of cyclin-A increases activation of associated kinases, even though CDK2 levels were not altered, leading to feedback activation of the estrogen receptor, further suppression of Fas expression, and neuro-protection.
Neg (not) Regulation (altered) of CDK2
6) Confidence 0.10 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.56 Pain Relevance 0
Upregulation of cyclinB1 also points to the G2/M checkpoint, which depends on cdk2/cyclinB1 activity.
Regulation (depends) of cdk2
7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.52 Pain Relevance 0.09
In order to explore the underlying molecular mechanism of CIAPIN1 affecting the cell cycle progression, we detected the expression of cell cycle-related molecules in AdSiCIAPIN1-infected SMMC-7721 cells, such as cyclinD1, p27, cdk2, cdk4 and p21 by western blot and found cdk2, cdk4 and p21 were not affected (data not show), except CyclyinD1 was downregulated and P27 was upregulated (Figure3F).
Neg (not) Regulation (affected) of cdk2
8) Confidence 0.05 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.03 Pain Relevance 0

General Comments

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