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Context Info
Confidence 0.80
First Reported 1980
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 210
Total Number 213
Disease Relevance 55.69
Pain Relevance 24.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (GCG) signal transduction (GCG) extracellular space (GCG)
small molecule metabolic process (GCG) extracellular region (GCG) plasma membrane (GCG)
Anatomy Link Frequency
plasma 6
blood 4
pancreas 4
brain 3
pituitary 2
GCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 683 100.00 Very High Very High Very High
Catecholamine 25 100.00 Very High Very High Very High
Serotonin 20 100.00 Very High Very High Very High
antagonist 876 99.96 Very High Very High Very High
Cholecystokinin 8 99.96 Very High Very High Very High
Clonidine 30 99.92 Very High Very High Very High
tetrodotoxin 1082 99.84 Very High Very High Very High
opiate 13 99.84 Very High Very High Very High
conotoxin 1296 99.68 Very High Very High Very High
narcan 23 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 46 100.00 Very High Very High Very High
Cv Unclassified Under Development 35 100.00 Very High Very High Very High
Hypoglycemia 2465 99.96 Very High Very High Very High
Diabetes Mellitus 3702 99.84 Very High Very High Very High
Gastric Motility Disorder 21 99.80 Very High Very High Very High
Brain Injury 8 99.48 Very High Very High Very High
Insulin Resistance 140 99.24 Very High Very High Very High
Hyperglycemia 110 99.20 Very High Very High Very High
Appetite Loss 21 99.04 Very High Very High Very High
Recurrence 20 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data uniquely demonstrate that: 1) intrahepatic islet transplant grafts secrete glucagon in response to arginine, but fail to secrete glucagon in response to sustained hypoglycemia; and 2) the restoration of sustained normoglycemia for over 2 years in type I diabetic patients may not reestablish glucagon responses from the native pancreas during hypoglycemia.
Localization (secrete) of glucagon in pancreas associated with hypoglycemia and diabetes mellitus
1) Confidence 0.80 Published 1997 Journal Diabetes Section Abstract Doc Link 8971076 Disease Relevance 0.61 Pain Relevance 0
Transplantation sites other than the liver may be required to achieve normal glucagon secretion from the transplanted islets.
Localization (secretion) of glucagon in liver
2) Confidence 0.80 Published 1997 Journal Diabetes Section Abstract Doc Link 8971076 Disease Relevance 0.33 Pain Relevance 0
Defective glucagon secretion during sustained hypoglycemia following successful islet allo- and autotransplantation in humans.
Localization (secretion) of glucagon associated with hypoglycemia
3) Confidence 0.80 Published 1997 Journal Diabetes Section Title Doc Link 8971076 Disease Relevance 0.74 Pain Relevance 0.09
These data uniquely demonstrate that: 1) intrahepatic islet transplant grafts secrete glucagon in response to arginine, but fail to secrete glucagon in response to sustained hypoglycemia; and 2) the restoration of sustained normoglycemia for over 2 years in type I diabetic patients may not reestablish glucagon responses from the native pancreas during hypoglycemia.
Localization (secrete) of glucagon in pancreas associated with hypoglycemia and diabetes mellitus
4) Confidence 0.80 Published 1997 Journal Diabetes Section Abstract Doc Link 8971076 Disease Relevance 0.61 Pain Relevance 0
Glucagon secretion was assessed during 3-h hypoglycemic hyperinsulinemic clamp studies.
Localization (secretion) of Glucagon
5) Confidence 0.80 Published 1997 Journal Diabetes Section Abstract Doc Link 8971076 Disease Relevance 0.80 Pain Relevance 0.08
We examined 1) whether intrahepatic islet autotransplantation provides glucagon secretion during prolonged periods of hypoglycemia and 2) whether intrahepatic islet allotransplantation in type I diabetic patients and consequent long-term normoglycemia reestablishes native alpha-cell responses to hypoglycemia.
Localization (secretion) of glucagon associated with hypoglycemia and diabetes mellitus
6) Confidence 0.80 Published 1997 Journal Diabetes Section Abstract Doc Link 8971076 Disease Relevance 0.79 Pain Relevance 0.09
During hypoglycemia, no increase in glucagon secretion was observed in either the auto- or allotransplant recipients, whereas healthy control subjects and recipients of kidney transplantation had significant increases in glucagon.
Localization (secretion) of glucagon in kidney associated with hypoglycemia
7) Confidence 0.80 Published 1997 Journal Diabetes Section Abstract Doc Link 8971076 Disease Relevance 0.68 Pain Relevance 0.05
Defective glucagon secretion during hypoglycemia is characteristic of long-standing type I diabetes.
Localization (secretion) of glucagon associated with hypoglycemia and diabetes mellitus
8) Confidence 0.80 Published 1997 Journal Diabetes Section Abstract Doc Link 8971076 Disease Relevance 0.56 Pain Relevance 0.08
These data indicate that in man clonidine-induced GH secretion is not mediated by a stimulatory effect of clonidine on glucagon secretion and that alpha-adrenergic mechanisms have little role in the regulation of basal glucagon secretion.
Localization (secretion) of glucagon associated with clonidine
9) Confidence 0.80 Published 1981 Journal Horm. Metab. Res. Section Abstract Doc Link 7308974 Disease Relevance 0 Pain Relevance 0.36
Effect of clonidine on growth hormone and glucagon secretion.
Localization (secretion) of glucagon associated with clonidine
10) Confidence 0.80 Published 1981 Journal Horm. Metab. Res. Section Title Doc Link 7308974 Disease Relevance 0 Pain Relevance 0.38
These data indicate that in man clonidine-induced GH secretion is not mediated by a stimulatory effect of clonidine on glucagon secretion and that alpha-adrenergic mechanisms have little role in the regulation of basal glucagon secretion.
Localization (secretion) of glucagon associated with clonidine
11) Confidence 0.80 Published 1981 Journal Horm. Metab. Res. Section Abstract Doc Link 7308974 Disease Relevance 0 Pain Relevance 0.35
GH and glucose increased but glucagon secretion remained unchanged.
Localization (secretion) of glucagon
12) Confidence 0.80 Published 1981 Journal Horm. Metab. Res. Section Abstract Doc Link 7308974 Disease Relevance 0 Pain Relevance 0.36
Glucagon secretion to ingestion of a mixed meal and to arginine infusion was not modified by the opioid receptor blocking agent.
Localization (secretion) of Glucagon associated with opioid receptor
13) Confidence 0.78 Published 1989 Journal Int J Obes Section Abstract Doc Link 2529225 Disease Relevance 0.52 Pain Relevance 0.47
This is mainly caused by the impaired glucagon secretion but also influenced by malnutrition and concomitant hepatic dysfunction due to the toxic affect of alcohol.
Localization (secretion) of glucagon associated with appetite loss, hepatotoxicity and alcohol
14) Confidence 0.78 Published 1999 Journal Z Gastroenterol Section Abstract Doc Link 10444809 Disease Relevance 1.30 Pain Relevance 0.51
Heterotopic pancreas transplantation in type I diabetic patients does not correct hyperglucagonemia, which is thought to be due to insufficiently suppressed glucagon release by the host pancreas.
Localization (release) of glucagon in pancreas associated with diabetes mellitus
15) Confidence 0.78 Published 1999 Journal Res Exp Med (Berl) Section Abstract Doc Link 10550640 Disease Relevance 0.18 Pain Relevance 0
High glucose levels may be a surrogate marker for the severity of brain injury incurred, reflecting the release of stress hormones (for example, cortisol, glucagon, and epinephrine).
Localization (release) of glucagon in brain associated with stress and brain injury
16) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2246198 Disease Relevance 0.57 Pain Relevance 0.04
These data uniquely demonstrate that: 1) intrahepatic islet transplant grafts secrete glucagon in response to arginine, but fail to secrete glucagon in response to sustained hypoglycemia; and 2) the restoration of sustained normoglycemia for over 2 years in type I diabetic patients may not reestablish glucagon responses from the native pancreas during hypoglycemia.
Localization (secrete) of glucagon in pancreas associated with hypoglycemia and diabetes mellitus
17) Confidence 0.75 Published 1997 Journal Diabetes Section Abstract Doc Link 8971076 Disease Relevance 0.61 Pain Relevance 0
Inhibition of dipeptidyl peptidase-4 (DPP-4) increases the concentration of glucagon-like peptide-1, an incretin hormone that stimulates glucose-dependent insulin release, suppresses glucagon production, slows gastric emptying, reduces appetite, and may promote preservation of ?
Localization (concentration) of glucagon
18) Confidence 0.73 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2584188 Disease Relevance 0.39 Pain Relevance 0
It is concluded that the capsaicin increases the glucose absorption from the gastrointestinal tract and increases the glucagon release (independently of the hormonal antagonist regulation by insulin released after glucose) loading during glucose loading tests carried out in human healthy subjects.
Localization (release) of glucagon associated with qutenza and antagonist
19) Confidence 0.70 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16612838 Disease Relevance 0 Pain Relevance 0.55
Finally, inhibitors of pancreatic secretion including somatostatin, calcitonin and glucagon showed no protective effect for PEP, yet maybe octreotide and beta-carotine administration had a beneficial effect.
Localization (secretion) of glucagon associated with pancreatitis and somatostatin
20) Confidence 0.68 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2921391 Disease Relevance 0.54 Pain Relevance 0.34

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