INT17668

Context Info Confidence 0.02 First Reported 1991 Last Reported 2006 Negated 0 Speculated 1 Reported most in Title Documents 5 Total Number 6 Disease Relevance 1.56 Pain Relevance 3.91

Anatomy Link Frequency dorsal horn 4 first segment 1 inferior 1 MCKD1 (Homo sapiens)

Pain Link Frequency Relevance Heat Dorsal horn 29 100.00 Morphine 8 99.82 nociceptor 6 99.76 tricyclic antidepressant 4 99.10 Spinal cord 12 98.96 narcan 2 97.78 inferior alveolar nerve 2 97.52 unmyelinated 2 97.28 glial activation 8 96.64 Stimulus evoked pain 6 95.92

Disease Link Frequency Relevance Heat Hypersensitivity 14 99.04 Nervous System Injury 4 97.44 Pain 6 95.24 Nociception 4 92.88 Ganglion Cysts 2 53.64 Neuropathic Pain 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In vivo electrochemical evidence that the tricyclic antidepressant femoxetine potentiates the morphine-induced increase in 5-HT metabolism in the medullary dorsal horn of freely moving rats.

Positive_regulation (increase) of medullary dorsal horn in dorsal horn associated with narcan, dorsal horn, tricyclic antidepressant and morphine

1) Confidence 0.02 Published 1991 Journal Brain Res. Section Title Doc Link 1933281 Disease Relevance 0 Pain Relevance 1.39

The noxious stimulus-dependent induction of c-Fos-like immunoreactivity (Fos-LI) in neurons in the subnucleus oralis and the medullary dorsal horn (MDH) was significantly suppressed by the selective destruction of unmyelinated primary neurons.

Positive_regulation (induction) of medullary dorsal horn in dorsal horn associated with dorsal horn and unmyelinated

2) Confidence 0.01 Published 2000 Journal Brain Res. Section Abstract Doc Link 10727645 Disease Relevance 0 Pain Relevance 0.51

Fos protein induction in the medullary dorsal horn and first segment of the spinal cord by tooth-pulp stimulation in cats.

Positive_regulation (induction) of medullary dorsal horn in dorsal horn associated with nociceptor, dorsal horn and spinal cord

3) Confidence 0.00 Published 1998 Journal Pain Section Title Doc Link 9539671 Disease Relevance 0.09 Pain Relevance 0.62

In this study, we investigated mechanisms by which glial cell activation in medullary dorsal horn (MDH) would contribute to tactile hypersensitivity following inferior alveolar nerve and mental nerve transection (IAMNT).

Spec (investigated) Positive_regulation (activation) of medullary dorsal horn in inferior associated with inferior alveolar nerve, hypersensitivity and dorsal horn

4) Confidence 0.00 Published 2006 Journal Pain Section Abstract Doc Link 16495005 Disease Relevance 0.61 Pain Relevance 0.36

Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury.

Positive_regulation (Activation) of medullary dorsal horn in dorsal horn associated with nervous system injury, hypersensitivity and dorsal horn

5) Confidence 0.00 Published 2006 Journal Pain Section Title Doc Link 16495005 Disease Relevance 0.76 Pain Relevance 0.42

Fos protein induction in the medullary dorsal horn and first segment of the spinal cord by tooth-pulp stimulation in cats.

Positive_regulation (induction) of medullary dorsal horn in first segment associated with nociceptor, dorsal horn and spinal cord

6) Confidence 0.00 Published 1998 Journal Pain Section Title Doc Link 9539671 Disease Relevance 0.09 Pain Relevance 0.62

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